Comparison of the Structural Changes Occurring during the Primary Phototransition of Two Different Channelrhodopsins from Chlamydomonas Algae

Channelrhodopsins (ChRs) from green flagellate algae function as light-gated ion channels when expressed heterologously in mammalian cells. Considerable interest has focused on understanding the molecular mechanisms of ChRs to bioengineer their properties for specific optogenetic applications such a...

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Veröffentlicht in:	Biochemistry (Easton) 2015-01, Vol.54 (2), p.377-388
Hauptverfasser:	Ogren, John I, Yi, Adrian, Mamaev, Sergey, Li, Hai, Lugtenburg, Johan, DeGrip, Willem J, Spudich, John L, Rothschild, Kenneth J
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriorhodopsins - chemistry Bacteriorhodopsins - genetics Chlamydomonas Chlamydomonas - chemistry Chlamydomonas - genetics Chlamydomonas reinhardtii Hydrogen Bonding Ion Channels - chemistry Ion Channels - genetics Isomerism Light Mutagenesis, Site-Directed Photochemical Processes Plant Proteins - chemistry Plant Proteins - genetics Protein Conformation Spectroscopy, Fourier Transform Infrared Water - chemistry
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