Nerve growth factor induces neurite outgrowth of PC12 cells by promoting Gβγ-microtubule interaction

Assembly and disassembly of microtubules (MTs) is critical for neurite outgrowth and differentiation. Evidence suggests that nerve growth factor (NGF) induces neurite outgrowth from PC12 cells by activating the receptor tyrosine kinase, TrkA. G protein-coupled receptors (GPCRs) as well as heterotrim...

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Veröffentlicht in:	BMC neuroscience 2014-12, Vol.15 (1), p.132-132, Article 132
Hauptverfasser:	Sierra-Fonseca, Jorge A, Najera, Omar, Martinez-Jurado, Jessica, Walker, Ellen M, Varela-Ramirez, Armando, Khan, Arshad M, Miranda, Manuel, Lamango, Nazarius S, Roychowdhury, Sukla
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carboxylic Ester Hydrolases - antagonists & inhibitors Carboxylic Ester Hydrolases - metabolism Cell Enlargement Cells, Cultured Cerebellum - cytology Cerebellum - physiology GTP-Binding Protein beta Subunits - metabolism GTP-Binding Protein gamma Subunits - metabolism Hippocampus - cytology Hippocampus - physiology Microtubules - metabolism Nerve Growth Factor - metabolism Neurites - physiology Neurogenesis - physiology Neurons - cytology Neurons - physiology PC12 Cells Rats Rats, Sprague-Dawley Tubulin - metabolism
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