A reduction of viral mRNA, proteins and induction of altered morphogenesis reveals the anti-HTLV-1 activity of the labdane-diterpene myriadenolide in vitro

Human T-lymphotropic virus 1 (HTLV-1) has been associated with leukemia/lymphoma (ATL) and myelopathy/tropical spastic paraparesis (HAM/TSP), in addition to other inflammatory diseases as well as infection complications. Therapeutic approaches for HTLV-1-related pathologies are limited. The labdane...

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Veröffentlicht in:	BMC microbiology 2014-12, Vol.14 (1), p.331-331, Article 331
Hauptverfasser:	Martins, Camila Pacheco Silveira, Gomes, Orlando Abreu, Martins, Marina Lobato, de Carvalho, Luciana Debortoli, de Souza, Jaqueline Gontijo, Da Fonseca, Flavio Guimaraes, dos Santos, Rodrigo Gonçalves Silva, Andrade, Margareth Spangler, Zani, Carlos Leomar, de Souza-Fagundes, Elaine Maria, Barbosa-Stancioli, Edel Figueiredo
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Anti-Inflammatory Agents - pharmacology Antiviral Agents - pharmacology Atomic force microscopy Biological Factors - pharmacology Biological Products - pharmacology Cell Line, Tumor Comparative analysis Cytotoxicity Diterpenes - pharmacology Ethanol Experiments Health aspects Herpesvirus Human immunodeficiency virus Human T-lymphotropic virus 1 Human T-lymphotropic virus 1 - drug effects Humans Jurkat Cells Leukemia Morphogenesis Morphogenesis - drug effects Proteins RNA, Messenger - genetics Transmission electron microscopy
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