PACT/RAX Regulates the Migration of Cerebellar Granule Neurons in the Developing Cerebellum

PACT and its murine ortholog RAX were originally identified as a protein activator for the dsRNA-dependent, interferon-inducible protein kinase PKR. Recent studies indicated that RAX played a role in embryogenesis and neuronal development. In this study, we investigated the expression of RAX during...

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Veröffentlicht in:	Scientific reports 2015-01, Vol.5 (1), p.7961-7961, Article 7961
Hauptverfasser:	Yong, Yue, Meng, Ya, Ding, Hanqing, Fan, Zhiqin, Tang, Yifen, Zhou, Chenghua, Luo, Jia, Ke, Zun-Ji
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/51 14/19 42/41 42/89 45/77 631/378/87 631/80/84/2027 64/60 82/51 96/106 Amino Acid Motifs Animals Carrier Proteins - metabolism Cell Differentiation Cell migration Cell Movement Cell Proliferation Cerebellum Cerebellum - growth & development Cytoplasmic Granules - metabolism Double-stranded RNA eIF-2 kinase eIF-2 Kinase - metabolism Embryogenesis Embryonic growth stage Eye Proteins - chemistry Eye Proteins - metabolism Focal adhesion kinase Focal Adhesion Protein-Tyrosine Kinases - metabolism Gene Knockdown Techniques Granule cells Homeodomain Proteins - chemistry Homeodomain Proteins - metabolism Humanities and Social Sciences Interferon Interferon-inducible protein Kinases Mice, Inbred C57BL multidisciplinary Neural stem cells Neuroglia - cytology Neuroglia - metabolism Neurons - cytology Neurons - metabolism Phosphorylation Protein Binding Protein kinase Rodents Science Transcription Factors - chemistry Transcription Factors - metabolism
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