High nuclear/cytoplasmic ratio of Cdk1 expression predicts poor prognosis in colorectal cancer patients

Cdk1 (cyclin-dependent kinase 1) is critical regulator of the G2-M checkpoint. Cyclin-dependent kinase pathways are considered possible targets for cancer treatment; however, the prognostic role of Cdk1 in colorectal cancer is still controversial. Therefore, we attempted to determine the impact of C...

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Veröffentlicht in:	BMC cancer 2014-12, Vol.14 (1), p.951-951, Article 951
Hauptverfasser:	Sung, Wen-Wei, Lin, Yueh-Min, Wu, Pei-Ru, Yen, Hsu-Heng, Lai, Hung-Wen, Su, Tzu-Cheng, Huang, Ren-Hung, Wen, Chun-Kai, Chen, Chia-Yu, Chen, Chih-Jung, Yeh, Kun-Tu
Format:	Artikel
Sprache:	eng
Schlagworte:	CDC2 Protein Kinase Cell division Cell Nucleus - metabolism Colorectal cancer Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Cyclin-dependent kinases Cyclin-Dependent Kinases - metabolism Cytoplasm Cytoplasm - metabolism Hospitals Humans Immunohistochemistry Kaplan-Meier Estimate Lung cancer Medical prognosis Metastasis Multivariate analysis Prognosis Proportional Hazards Models Review boards Survival Analysis Tumors
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