Transgenic overexpression of mitofilin attenuates diabetes mellitus-associated cardiac and mitochondria dysfunction

Abstract Mitofilin, also known as heart muscle protein, is an inner mitochondrial membrane structural protein that plays a central role in maintaining cristae morphology and structure. It is a critical component of the mitochondrial contact site and cristae organizing system (MICOS) complex which is...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2015-02, Vol.79, p.212-223
Hauptverfasser:	Thapa, Dharendra, Nichols, Cody E, Lewis, Sara E, Shepherd, Danielle L, Jagannathan, Rajaganapathi, Croston, Tara L, Tveter, Kevin J, Holden, Anthony A, Baseler, Walter A, Hollander, John M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Body Weight Cardiovascular Diabetes mellitus Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Experimental - physiopathology Electron Transport Electron transport chain Heart - physiopathology Humans Lipid Peroxidation Male Membrane Potential, Mitochondrial Mice, Transgenic Mitochondria Mitochondria, Heart - metabolism Mitochondria, Heart - ultrastructure Mitochondrial Dynamics Mitochondrial Proteins - metabolism Mitofilin Muscle Proteins - metabolism Myocardial Contraction Native Polyacrylamide Gel Electrophoresis Organ Size Oxidative Stress
Online-Zugang:	Volltext
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