Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay

ABHD16A is identified as a major enzyme catalyzing production of lyso-PS from phosphatidylserine (PS). A new ABHD16A inhibitor and knockout mice show a dynamic interplay occurring during inflammation between ABHD16A and disease-linked ABHD12, an enzyme that degrades lyso-PS. ABHD16A is identified as...

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Veröffentlicht in:	Nature chemical biology 2015-02, Vol.11 (2), p.164-171
Hauptverfasser:	Kamat, Siddhesh S, Camara, Kaddy, Parsons, William H, Chen, Dong-Hui, Dix, Melissa M, Bird, Thomas D, Howell, Amy R, Cravatt, Benjamin F
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250 631/45 631/92/287 631/92/607 82 82/58 Animals Biochemical Engineering Biochemistry Bioorganic Chemistry Brain Brain - enzymology Brain - immunology Brain - metabolism Cell Biology Cell Line Chemistry Chemistry/Food Science Cytokines - immunology Cytokines - metabolism Hearing loss Humans Immunologic Factors - immunology Immunologic Factors - metabolism Immunology Lipids Lysophospholipids - immunology Lysophospholipids - metabolism Macrophages - enzymology Macrophages - immunology Macrophages - metabolism Male Mammals Metabolism Mice, Knockout Monoacylglycerol Lipases - genetics Mutation Phospholipases - antagonists & inhibitors Phospholipases - genetics Signaling
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