Regioselective Gold-Catalyzed Oxidative C–N Bond Formation
A novel protocol for the regioselective intermolecular amination of various arenes has been developed. By using an I(III) oxidant in the presence of a Au(I) catalyst, a direct and novel route for regioselectively accessing a variety of substituted aniline moieties has been achieved with yields as...
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| Veröffentlicht in: | Organic letters 2015-01, Vol.17 (2), p.358-361 |
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| container_end_page | 361 |
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| container_issue | 2 |
| container_start_page | 358 |
| container_title | Organic letters |
| container_volume | 17 |
| creator | Marchetti, Louis Kantak, Abhishek Davis, Riley DeBoef, Brenton |
| description | A novel protocol for the regioselective intermolecular amination of various arenes has been developed. By using an I(III) oxidant in the presence of a Au(I) catalyst, a direct and novel route for regioselectively accessing a variety of substituted aniline moieties has been achieved with yields as high as 90%. Mechanistic insight suggests that regioselectivity can be predicted based on electrophilic aromatic metalation patterns. |
| doi_str_mv | 10.1021/ol5034805 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1523-7060 |
| ispartof | Organic letters, 2015-01, Vol.17 (2), p.358-361 |
| issn | 1523-7060 1523-7052 1523-7052 |
| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Amination aniline Aniline Compounds - chemical synthesis Aniline Compounds - chemistry aromatic hydrocarbons Catalysis catalysts chemical bonding gold Gold - chemistry Letter Lewis acids moieties Molecular Structure Organometallic Compounds - chemistry oxidants Oxidation-Reduction regioselectivity Stereoisomerism |
| title | Regioselective Gold-Catalyzed Oxidative C–N Bond Formation |
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