The nsp3 macrodomain promotes virulence in mice with coronavirus-induced encephalitis

All coronaviruses encode a macrodomain containing ADP-ribose-1"-phosphatase (ADRP) activity within the N terminus of nonstructural protein 3 (nsp3). Previous work showed that mouse hepatitis virus strain A59 (MHV-A59) with a mutated catalytic site (N1348A) replicated similarly to wild-type viru...

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Veröffentlicht in:	Journal of virology 2015-02, Vol.89 (3), p.1523-1536
Hauptverfasser:	Fehr, Anthony R, Athmer, Jeremiah, Channappanavar, Rudragouda, Phillips, Judith M, Meyerholz, David K, Perlman, Stanley
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Weight Brain - immunology Brain - pathology Coronavirus Cytokines - metabolism Disease Models, Animal Encephalitis, Viral - pathology Encephalitis, Viral - virology Leukocytes - immunology Male Mice, Inbred C57BL Murine hepatitis virus Murine hepatitis virus - genetics Murine hepatitis virus - growth & development Murine hepatitis virus - pathogenicity Mutant Proteins - genetics Mutant Proteins - metabolism Mutation, Missense Pathogenesis and Immunity Point Mutation Survival Analysis Viral Load Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism Virulence Virulence Factors - genetics Virulence Factors - metabolism
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