Anti-Obesity and Anti-Hyperglycemic Effects of Cinnamaldehyde via altered Ghrelin Secretion and Functional impact on Food Intake and Gastric Emptying

Cinnamon extract is associated to different health benefits but the active ingredients or pathways are unknown. Cinnamaldehyde (CIN) imparts the characteristic flavor to cinnamon and is known to be the main agonist of transient receptor potential-ankyrin receptor 1 (TRPA1). Here, expression of TRPA1...

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Veröffentlicht in:	Scientific reports 2015-01, Vol.5 (1), p.7919, Article 7919
Hauptverfasser:	Camacho, Susana, Michlig, Stephanie, de Senarclens-Bezençon, Carole, Meylan, Jenny, Meystre, Julie, Pezzoli, Maurizio, Markram, Henry, le Coutre, Johannes
Format:	Artikel
Sprache:	eng
Schlagworte:	14/1 14/32 38/88 631/378/3917 631/443/319/1488/393 692/700/2814 82/29 Acrolein - analogs & derivatives Acrolein - pharmacology Adipose tissue Animals Ankyrins Anti-Obesity Agents - pharmacology Body weight Body weight gain Cell culture Cell Line Cinnamaldehyde Cinnamon Duodenum Eating - drug effects Eating - genetics Epithelial Cells - secretion Flavor Food intake Gastric emptying Gastric Emptying - drug effects Gastric Emptying - genetics Gastric Mucosa - metabolism Gene Expression Regulation - drug effects Gene regulation Ghrelin Ghrelin - genetics Ghrelin - secretion Glucose tolerance Humanities and Social Sciences Hyperglycemia Hypoglycemic Agents - pharmacology Insulin Insulin secretion Localization Mice Mice, Knockout Mice, Obese multidisciplinary Obesity Oxidation Rodents Science Secretion Stomach Transient Receptor Potential Channels - biosynthesis Transient Receptor Potential Channels - genetics Transient receptor potential proteins TRPA1 Cation Channel
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