Variant allele frequency enrichment analysis in vitro reveals sonic hedgehog pathway to impede sustained temozolomide response in GBM

Neoplastic cells of Glioblastoma multiforme (GBM) may or may not show sustained response to temozolomide (TMZ) chemotherapy. We hypothesize that TMZ chemotherapy response in GBM is predetermined in its neoplastic clones via a specific set of mutations that alter relevant pathways. We describe exome-...

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Veröffentlicht in:	Scientific reports 2015-01, Vol.5 (1), p.7915-7915, Article 7915
Hauptverfasser:	Biswas, Nidhan K., Chandra, Vikas, Sarkar-Roy, Neeta, Das, Tapojyoti, Bhattacharya, Rabindra N., Tripathy, Laxmi N., Basu, Sunandan K., Kumar, Shantanu, Das, Subrata, Chatterjee, Ankita, Mukherjee, Ankur, Basu, Pryiadarshi, Maitra, Arindam, Chattopadhyay, Ansuman, Basu, Analabha, Dhara, Surajit
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 13/2 13/31 38/88 45/23 631/67/1922 692/699/67/69 Alleles Anilides - pharmacology Cell Division - drug effects Cell Division - genetics Cell Line, Tumor Chemotherapy Dacarbazine - administration & dosage Dacarbazine - analogs & derivatives Exome Female Follow-Up Studies G2 Phase - drug effects G2 Phase - genetics Gene expression Gene Frequency Glioblastoma Glioblastoma - diagnostic imaging Glioblastoma - drug therapy Glioblastoma - genetics Glioblastoma - metabolism Hedgehog protein Hedgehog Proteins - genetics Hedgehog Proteins - metabolism Humanities and Social Sciences Humans Lysine Male Malignancy multidisciplinary Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neurospheres Non-homologous end joining Phenylalanine Population genetics Pyridines - pharmacology Radiography Ribonucleic acid RNA Science Spheroids, Cellular - metabolism Spheroids, Cellular - pathology Temozolomide
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