IL-33-dependent type 2 inflammation during rhinovirus-induced asthma exacerbations in vivo

Rhinoviruses are the major cause of asthma exacerbations; however, its underlying mechanisms are poorly understood. We hypothesized that the epithelial cell-derived cytokine IL-33 plays a central role in exacerbation pathogenesis through augmentation of type 2 inflammation. To assess whether rhinovi...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2014-12, Vol.190 (12), p.1373-1382
Hauptverfasser:	Jackson, David J, Makrinioti, Heidi, Rana, Batika M J, Shamji, Betty W H, Trujillo-Torralbo, Maria-Belen, Footitt, Joseph, Jerico Del-Rosario, Telcian, Aurica G, Nikonova, Alexandra, Zhu, Jie, Aniscenko, Julia, Gogsadze, Leila, Bakhsoliani, Eteri, Traub, Stephanie, Dhariwal, Jaideep, Porter, James, Hunt, Duncan, Hunt, Toby, Hunt, Trevor, Stanciu, Luminita A, Khaitov, Musa, Bartlett, Nathan W, Edwards, Michael R, Kon, Onn Min, Mallia, Patrick, Papadopoulos, Nikolaos G, Akdis, Cezmi A, Westwick, John, Edwards, Matthew J, Cousins, David J, Walton, Ross P, Johnston, Sebastian L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Asthma - etiology Asthma - physiopathology Asthma - virology Cells, Cultured Female Humans Inflammation - etiology Inflammation - physiopathology Interleukin-13 - physiology Interleukin-33 Interleukin-4 - physiology Interleukin-5 - physiology Interleukins - physiology Lymphocyte Subsets - physiology Male Original Picornaviridae Infections - complications Picornaviridae Infections - physiopathology Rhinovirus Severity of Illness Index T-Lymphocytes - physiology Th2 Cells - physiology Viral Load
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