Albumin and magnetic resonance imaging-liver volume to identify hepatitis B-related cirrhosis and esophageal varices
AIM:To investigate whether liver lobe volume and albumin(ALB) could predict the presence and severity of liver cirrhosis,and esophageal varices.METHODS:Seventy-one cirrhotic patients with hepatitis B and 21 healthy individuals were enrolled in this study.All the participants underwent abdominal enha...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2015-01, Vol.21 (3), p.988-996 |
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| creator | Li, Hang Chen, Tian-Wu Li, Zhen-Lin Zhang, Xiao-Ming Li, Cheng-Jun Chen, Xiao-Li Chen, Guang-Wen Hu, Jia-Ni Ye, Yong-Quan |
| description | AIM:To investigate whether liver lobe volume and albumin(ALB) could predict the presence and severity of liver cirrhosis,and esophageal varices.METHODS:Seventy-one cirrhotic patients with hepatitis B and 21 healthy individuals were enrolled in this study.All the participants underwent abdominal enhanced magnetic resonance imaging to measure each liver lobe volume,and biochemical workup for testing ALB and Child-Pugh class.All cirrhotic patients underwent upper gastrointestinal endoscopy to show the presence of cirrhotic esophageal varices.Right liver lobe volume(RV),left medial liver lobe volume(LMV),left lateral liver lobe volume(LLV),and caudate lobe volume(CV) were measured using enhanced magnetic resonance imaging.The ratios of RV to ALB(RV/ALB),LMV to ALB(LMV/ALB),LLV to ALB(LLV/ALB) and CV to ALB(CV/ALB) were calculated.Statistical analyses were performed to determine whether and how the combination of liver lobe volume measured using magnetic resonance imaging and albumin could predict the presence and severity of liver cirrhosis,and the presence of esophageal varices.RESULTS:RV,LMV,LLV and CV decreased(r =-0.51-0.373; all P < 0.05),while RV/ALB increased(r = 0.424; P < 0.05),with the progress of Child-Pugh classof liver cirrhosis.RV,LMV,CV,LLV/ALB and CV/ALB could identify presence of liver cirrhosis; LLV and LMV could distinguish Child-Pugh class A from B; RV,LMV,LLV,CV,RV/ALB and LLV/ALB could distinguish class A from C; RV and LLV/ALB could differentiate B from C; and RV,RV/ALB and CV/ALB could identify presence of esophageal varices(all P < 0.05).Among these parameters,CV/ALB could best identify the presence of liver cirrhosis,with an area under receiver operating characteristic curve(AUC) of 0.860,a sensitivity of 82.0% and a specificity of 83.0%.LLV could best distinguish class A from B,with an AUC of 0.761,a sensitivity of 74.4% and a specificity of 73.1%.RV could best distinguish class A from C,with an AUC of 0.900,a sensitivity of 90.3% and a specificity of 84.5%.LLV/ALB could best distinguish class B from C,with an AUC of 0.900,a sensitivity of 93.8% and a specificity of 81.5%.RV/ALB could best identify esophageal varices,with an AUC of 0.890,a sensitivity of 80.0% and a specificity of 83.5%.CONCLUSION:The combination of liver lobe volume and ALB has potential to identify presence and severity of cirrhosis,and presence of esophageal varices. |
| doi_str_mv | 10.3748/wjg.v21.i3.988 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4299354</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>90888889504849534851485057</cqvip_id><sourcerecordid>1652413379</sourcerecordid><originalsourceid>FETCH-LOGICAL-c434t-c387c4437620b8c4ce52355c7645717beb038c373f495585dab4012759644cc33</originalsourceid><addsrcrecordid>eNpVkc-L3CAUx6W0dKfbXnssHntJqj6Neilsl_6ChV7asxjjZFwSndUkZf_7Oux0aAURnl8_vscHobeUtCC5-vD7fmw3RtsArVbqGdoxRnXDFCfP0Y4SIhsNTF6hV6XcE8IABHuJrpjoGJcgdmi5mfp1DhHbOODZjtEvweHsS4o2Oo9DrYU4NlPYfMZbmtbZ4yXhMPi4hP0jPvijXcISCv7UZD_ZxQ_YhZwPqdTaiVpZx4MdvZ3wZnNwvrxGL_Z2Kv7N-bxGv758_nn7rbn78fX77c1d4zjwpXGgpOMcZMdIrxx3XjAQwsmOC0ll73sCyoGEPddCKDHYnhPKpNAd584BXKOPT9zj2s9-cLXlbCdzzHWq_GiSDeb_mxgOZkyb4UxrELwC3p8BOT2svixmDsX5abLRp7UY2gnGKYDUNdo-RV1OpWS_v3xDiTmpMlWVqapMAFNV1Qfv_m3uEv_rpgbgTDykOD5UC5eMJuq0tCBc1dmBK0HrJkLCHyTZoeo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1652413379</pqid></control><display><type>article</type><title>Albumin and magnetic resonance imaging-liver volume to identify hepatitis B-related cirrhosis and esophageal varices</title><source>MEDLINE</source><source>Baishideng "World Journal of" online journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Li, Hang ; Chen, Tian-Wu ; Li, Zhen-Lin ; Zhang, Xiao-Ming ; Li, Cheng-Jun ; Chen, Xiao-Li ; Chen, Guang-Wen ; Hu, Jia-Ni ; Ye, Yong-Quan</creator><creatorcontrib>Li, Hang ; Chen, Tian-Wu ; Li, Zhen-Lin ; Zhang, Xiao-Ming ; Li, Cheng-Jun ; Chen, Xiao-Li ; Chen, Guang-Wen ; Hu, Jia-Ni ; Ye, Yong-Quan</creatorcontrib><description>AIM:To investigate whether liver lobe volume and albumin(ALB) could predict the presence and severity of liver cirrhosis,and esophageal varices.METHODS:Seventy-one cirrhotic patients with hepatitis B and 21 healthy individuals were enrolled in this study.All the participants underwent abdominal enhanced magnetic resonance imaging to measure each liver lobe volume,and biochemical workup for testing ALB and Child-Pugh class.All cirrhotic patients underwent upper gastrointestinal endoscopy to show the presence of cirrhotic esophageal varices.Right liver lobe volume(RV),left medial liver lobe volume(LMV),left lateral liver lobe volume(LLV),and caudate lobe volume(CV) were measured using enhanced magnetic resonance imaging.The ratios of RV to ALB(RV/ALB),LMV to ALB(LMV/ALB),LLV to ALB(LLV/ALB) and CV to ALB(CV/ALB) were calculated.Statistical analyses were performed to determine whether and how the combination of liver lobe volume measured using magnetic resonance imaging and albumin could predict the presence and severity of liver cirrhosis,and the presence of esophageal varices.RESULTS:RV,LMV,LLV and CV decreased(r =-0.51-0.373; all P &lt; 0.05),while RV/ALB increased(r = 0.424; P &lt; 0.05),with the progress of Child-Pugh classof liver cirrhosis.RV,LMV,CV,LLV/ALB and CV/ALB could identify presence of liver cirrhosis; LLV and LMV could distinguish Child-Pugh class A from B; RV,LMV,LLV,CV,RV/ALB and LLV/ALB could distinguish class A from C; RV and LLV/ALB could differentiate B from C; and RV,RV/ALB and CV/ALB could identify presence of esophageal varices(all P &lt; 0.05).Among these parameters,CV/ALB could best identify the presence of liver cirrhosis,with an area under receiver operating characteristic curve(AUC) of 0.860,a sensitivity of 82.0% and a specificity of 83.0%.LLV could best distinguish class A from B,with an AUC of 0.761,a sensitivity of 74.4% and a specificity of 73.1%.RV could best distinguish class A from C,with an AUC of 0.900,a sensitivity of 90.3% and a specificity of 84.5%.LLV/ALB could best distinguish class B from C,with an AUC of 0.900,a sensitivity of 93.8% and a specificity of 81.5%.RV/ALB could best identify esophageal varices,with an AUC of 0.890,a sensitivity of 80.0% and a specificity of 83.5%.CONCLUSION:The combination of liver lobe volume and ALB has potential to identify presence and severity of cirrhosis,and presence of esophageal varices.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v21.i3.988</identifier><identifier>PMID: 25624735</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Inc</publisher><subject>Adult ; Aged ; Area Under Curve ; Biomarkers - blood ; Case-Control Studies ; cirrhosis;Liver ; Contrast Media ; Disease Progression ; Endoscopy, Gastrointestinal ; Esophageal and Gastric Varices - blood ; Esophageal and Gastric Varices - diagnosis ; Esophageal and Gastric Varices - pathology ; Esophageal and Gastric Varices - virology ; Female ; Gadolinium DTPA ; Hepatitis B - complications ; Hepatitis B - diagnosis ; Humans ; imaging;Liver ; Liver - pathology ; Liver - virology ; Liver Cirrhosis - blood ; Liver Cirrhosis - diagnosis ; Liver Cirrhosis - pathology ; Liver Cirrhosis - virology ; Magnetic ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Observer Variation ; Organ Size ; Predictive Value of Tests ; Prospective Studies ; Prospective Study ; Reproducibility of Results ; resonance ; ROC Curve ; Serum Albumin - analysis ; Serum Albumin, Human ; Severity of Illness Index</subject><ispartof>World journal of gastroenterology : WJG, 2015-01, Vol.21 (3), p.988-996</ispartof><rights>The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. 2015</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-c387c4437620b8c4ce52355c7645717beb038c373f495585dab4012759644cc33</citedby><cites>FETCH-LOGICAL-c434t-c387c4437620b8c4ce52355c7645717beb038c373f495585dab4012759644cc33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299354/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299354/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25624735$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Hang</creatorcontrib><creatorcontrib>Chen, Tian-Wu</creatorcontrib><creatorcontrib>Li, Zhen-Lin</creatorcontrib><creatorcontrib>Zhang, Xiao-Ming</creatorcontrib><creatorcontrib>Li, Cheng-Jun</creatorcontrib><creatorcontrib>Chen, Xiao-Li</creatorcontrib><creatorcontrib>Chen, Guang-Wen</creatorcontrib><creatorcontrib>Hu, Jia-Ni</creatorcontrib><creatorcontrib>Ye, Yong-Quan</creatorcontrib><title>Albumin and magnetic resonance imaging-liver volume to identify hepatitis B-related cirrhosis and esophageal varices</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM:To investigate whether liver lobe volume and albumin(ALB) could predict the presence and severity of liver cirrhosis,and esophageal varices.METHODS:Seventy-one cirrhotic patients with hepatitis B and 21 healthy individuals were enrolled in this study.All the participants underwent abdominal enhanced magnetic resonance imaging to measure each liver lobe volume,and biochemical workup for testing ALB and Child-Pugh class.All cirrhotic patients underwent upper gastrointestinal endoscopy to show the presence of cirrhotic esophageal varices.Right liver lobe volume(RV),left medial liver lobe volume(LMV),left lateral liver lobe volume(LLV),and caudate lobe volume(CV) were measured using enhanced magnetic resonance imaging.The ratios of RV to ALB(RV/ALB),LMV to ALB(LMV/ALB),LLV to ALB(LLV/ALB) and CV to ALB(CV/ALB) were calculated.Statistical analyses were performed to determine whether and how the combination of liver lobe volume measured using magnetic resonance imaging and albumin could predict the presence and severity of liver cirrhosis,and the presence of esophageal varices.RESULTS:RV,LMV,LLV and CV decreased(r =-0.51-0.373; all P &lt; 0.05),while RV/ALB increased(r = 0.424; P &lt; 0.05),with the progress of Child-Pugh classof liver cirrhosis.RV,LMV,CV,LLV/ALB and CV/ALB could identify presence of liver cirrhosis; LLV and LMV could distinguish Child-Pugh class A from B; RV,LMV,LLV,CV,RV/ALB and LLV/ALB could distinguish class A from C; RV and LLV/ALB could differentiate B from C; and RV,RV/ALB and CV/ALB could identify presence of esophageal varices(all P &lt; 0.05).Among these parameters,CV/ALB could best identify the presence of liver cirrhosis,with an area under receiver operating characteristic curve(AUC) of 0.860,a sensitivity of 82.0% and a specificity of 83.0%.LLV could best distinguish class A from B,with an AUC of 0.761,a sensitivity of 74.4% and a specificity of 73.1%.RV could best distinguish class A from C,with an AUC of 0.900,a sensitivity of 90.3% and a specificity of 84.5%.LLV/ALB could best distinguish class B from C,with an AUC of 0.900,a sensitivity of 93.8% and a specificity of 81.5%.RV/ALB could best identify esophageal varices,with an AUC of 0.890,a sensitivity of 80.0% and a specificity of 83.5%.CONCLUSION:The combination of liver lobe volume and ALB has potential to identify presence and severity of cirrhosis,and presence of esophageal varices.</description><subject>Adult</subject><subject>Aged</subject><subject>Area Under Curve</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>cirrhosis;Liver</subject><subject>Contrast Media</subject><subject>Disease Progression</subject><subject>Endoscopy, Gastrointestinal</subject><subject>Esophageal and Gastric Varices - blood</subject><subject>Esophageal and Gastric Varices - diagnosis</subject><subject>Esophageal and Gastric Varices - pathology</subject><subject>Esophageal and Gastric Varices - virology</subject><subject>Female</subject><subject>Gadolinium DTPA</subject><subject>Hepatitis B - complications</subject><subject>Hepatitis B - diagnosis</subject><subject>Humans</subject><subject>imaging;Liver</subject><subject>Liver - pathology</subject><subject>Liver - virology</subject><subject>Liver Cirrhosis - blood</subject><subject>Liver Cirrhosis - diagnosis</subject><subject>Liver Cirrhosis - pathology</subject><subject>Liver Cirrhosis - virology</subject><subject>Magnetic</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Observer Variation</subject><subject>Organ Size</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Prospective Study</subject><subject>Reproducibility of Results</subject><subject>resonance</subject><subject>ROC Curve</subject><subject>Serum Albumin - analysis</subject><subject>Serum Albumin, Human</subject><subject>Severity of Illness Index</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc-L3CAUx6W0dKfbXnssHntJqj6Neilsl_6ChV7asxjjZFwSndUkZf_7Oux0aAURnl8_vscHobeUtCC5-vD7fmw3RtsArVbqGdoxRnXDFCfP0Y4SIhsNTF6hV6XcE8IABHuJrpjoGJcgdmi5mfp1DhHbOODZjtEvweHsS4o2Oo9DrYU4NlPYfMZbmtbZ4yXhMPi4hP0jPvijXcISCv7UZD_ZxQ_YhZwPqdTaiVpZx4MdvZ3wZnNwvrxGL_Z2Kv7N-bxGv758_nn7rbn78fX77c1d4zjwpXGgpOMcZMdIrxx3XjAQwsmOC0ll73sCyoGEPddCKDHYnhPKpNAd584BXKOPT9zj2s9-cLXlbCdzzHWq_GiSDeb_mxgOZkyb4UxrELwC3p8BOT2svixmDsX5abLRp7UY2gnGKYDUNdo-RV1OpWS_v3xDiTmpMlWVqapMAFNV1Qfv_m3uEv_rpgbgTDykOD5UC5eMJuq0tCBc1dmBK0HrJkLCHyTZoeo</recordid><startdate>20150121</startdate><enddate>20150121</enddate><creator>Li, Hang</creator><creator>Chen, Tian-Wu</creator><creator>Li, Zhen-Lin</creator><creator>Zhang, Xiao-Ming</creator><creator>Li, Cheng-Jun</creator><creator>Chen, Xiao-Li</creator><creator>Chen, Guang-Wen</creator><creator>Hu, Jia-Ni</creator><creator>Ye, Yong-Quan</creator><general>Baishideng Publishing Group Inc</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150121</creationdate><title>Albumin and magnetic resonance imaging-liver volume to identify hepatitis B-related cirrhosis and esophageal varices</title><author>Li, Hang ; Chen, Tian-Wu ; Li, Zhen-Lin ; Zhang, Xiao-Ming ; Li, Cheng-Jun ; Chen, Xiao-Li ; Chen, Guang-Wen ; Hu, Jia-Ni ; Ye, Yong-Quan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-c387c4437620b8c4ce52355c7645717beb038c373f495585dab4012759644cc33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Area Under Curve</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>cirrhosis;Liver</topic><topic>Contrast Media</topic><topic>Disease Progression</topic><topic>Endoscopy, Gastrointestinal</topic><topic>Esophageal and Gastric Varices - blood</topic><topic>Esophageal and Gastric Varices - diagnosis</topic><topic>Esophageal and Gastric Varices - pathology</topic><topic>Esophageal and Gastric Varices - virology</topic><topic>Female</topic><topic>Gadolinium DTPA</topic><topic>Hepatitis B - complications</topic><topic>Hepatitis B - diagnosis</topic><topic>Humans</topic><topic>imaging;Liver</topic><topic>Liver - pathology</topic><topic>Liver - virology</topic><topic>Liver Cirrhosis - blood</topic><topic>Liver Cirrhosis - diagnosis</topic><topic>Liver Cirrhosis - pathology</topic><topic>Liver Cirrhosis - virology</topic><topic>Magnetic</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Observer Variation</topic><topic>Organ Size</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Prospective Study</topic><topic>Reproducibility of Results</topic><topic>resonance</topic><topic>ROC Curve</topic><topic>Serum Albumin - analysis</topic><topic>Serum Albumin, Human</topic><topic>Severity of Illness Index</topic><toplevel>online_resources</toplevel><creatorcontrib>Li, Hang</creatorcontrib><creatorcontrib>Chen, Tian-Wu</creatorcontrib><creatorcontrib>Li, Zhen-Lin</creatorcontrib><creatorcontrib>Zhang, Xiao-Ming</creatorcontrib><creatorcontrib>Li, Cheng-Jun</creatorcontrib><creatorcontrib>Chen, Xiao-Li</creatorcontrib><creatorcontrib>Chen, Guang-Wen</creatorcontrib><creatorcontrib>Hu, Jia-Ni</creatorcontrib><creatorcontrib>Ye, Yong-Quan</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Hang</au><au>Chen, Tian-Wu</au><au>Li, Zhen-Lin</au><au>Zhang, Xiao-Ming</au><au>Li, Cheng-Jun</au><au>Chen, Xiao-Li</au><au>Chen, Guang-Wen</au><au>Hu, Jia-Ni</au><au>Ye, Yong-Quan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Albumin and magnetic resonance imaging-liver volume to identify hepatitis B-related cirrhosis and esophageal varices</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2015-01-21</date><risdate>2015</risdate><volume>21</volume><issue>3</issue><spage>988</spage><epage>996</epage><pages>988-996</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM:To investigate whether liver lobe volume and albumin(ALB) could predict the presence and severity of liver cirrhosis,and esophageal varices.METHODS:Seventy-one cirrhotic patients with hepatitis B and 21 healthy individuals were enrolled in this study.All the participants underwent abdominal enhanced magnetic resonance imaging to measure each liver lobe volume,and biochemical workup for testing ALB and Child-Pugh class.All cirrhotic patients underwent upper gastrointestinal endoscopy to show the presence of cirrhotic esophageal varices.Right liver lobe volume(RV),left medial liver lobe volume(LMV),left lateral liver lobe volume(LLV),and caudate lobe volume(CV) were measured using enhanced magnetic resonance imaging.The ratios of RV to ALB(RV/ALB),LMV to ALB(LMV/ALB),LLV to ALB(LLV/ALB) and CV to ALB(CV/ALB) were calculated.Statistical analyses were performed to determine whether and how the combination of liver lobe volume measured using magnetic resonance imaging and albumin could predict the presence and severity of liver cirrhosis,and the presence of esophageal varices.RESULTS:RV,LMV,LLV and CV decreased(r =-0.51-0.373; all P &lt; 0.05),while RV/ALB increased(r = 0.424; P &lt; 0.05),with the progress of Child-Pugh classof liver cirrhosis.RV,LMV,CV,LLV/ALB and CV/ALB could identify presence of liver cirrhosis; LLV and LMV could distinguish Child-Pugh class A from B; RV,LMV,LLV,CV,RV/ALB and LLV/ALB could distinguish class A from C; RV and LLV/ALB could differentiate B from C; and RV,RV/ALB and CV/ALB could identify presence of esophageal varices(all P &lt; 0.05).Among these parameters,CV/ALB could best identify the presence of liver cirrhosis,with an area under receiver operating characteristic curve(AUC) of 0.860,a sensitivity of 82.0% and a specificity of 83.0%.LLV could best distinguish class A from B,with an AUC of 0.761,a sensitivity of 74.4% and a specificity of 73.1%.RV could best distinguish class A from C,with an AUC of 0.900,a sensitivity of 90.3% and a specificity of 84.5%.LLV/ALB could best distinguish class B from C,with an AUC of 0.900,a sensitivity of 93.8% and a specificity of 81.5%.RV/ALB could best identify esophageal varices,with an AUC of 0.890,a sensitivity of 80.0% and a specificity of 83.5%.CONCLUSION:The combination of liver lobe volume and ALB has potential to identify presence and severity of cirrhosis,and presence of esophageal varices.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Inc</pub><pmid>25624735</pmid><doi>10.3748/wjg.v21.i3.988</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | World journal of gastroenterology : WJG, 2015-01, Vol.21 (3), p.988-996 |
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| source | MEDLINE; Baishideng "World Journal of" online journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Aged Area Under Curve Biomarkers - blood Case-Control Studies cirrhosis Liver Contrast Media Disease Progression Endoscopy, Gastrointestinal Esophageal and Gastric Varices - blood Esophageal and Gastric Varices - diagnosis Esophageal and Gastric Varices - pathology Esophageal and Gastric Varices - virology Female Gadolinium DTPA Hepatitis B - complications Hepatitis B - diagnosis Humans imaging Liver Liver - pathology Liver - virology Liver Cirrhosis - blood Liver Cirrhosis - diagnosis Liver Cirrhosis - pathology Liver Cirrhosis - virology Magnetic Magnetic Resonance Imaging Male Middle Aged Observer Variation Organ Size Predictive Value of Tests Prospective Studies Prospective Study Reproducibility of Results resonance ROC Curve Serum Albumin - analysis Serum Albumin, Human Severity of Illness Index |
| title | Albumin and magnetic resonance imaging-liver volume to identify hepatitis B-related cirrhosis and esophageal varices |
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