RhoC,vascular endothelial growth factor and microvascular density in esophageal squamous cell carcinoma
AIM:To investigate the expression of Ras homolog(Rho)C,vascular endothelial growth factor(VEGF) and CD105 in esophageal squamous cell carcinoma.METHODS:Semi-quantitative reverse transcriptase polymerase chain reaction,in situ hybridization and immunohistochemical streptavidin-biotin- peroxidase meth...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2015-01, Vol.21 (3), p.905-912 |
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| creator | Zhao, Zhi-Hua Tian, Yan Yang, Jian-Pin Zhou, Jun Chen, Kui-Sheng |
| description | AIM:To investigate the expression of Ras homolog(Rho)C,vascular endothelial growth factor(VEGF) and CD105 in esophageal squamous cell carcinoma.METHODS:Semi-quantitative reverse transcriptase polymerase chain reaction,in situ hybridization and immunohistochemical streptavidin-biotin- peroxidase methods were used to detect expression of Rho C m RNA and protein,and VEGF protein in 62 cases with esophageal squamous cell carcinoma,31 cases with adjacent atypical hyperplastic tissues,and 62 cases with normal esophageal mucosa.CD105 antibody labeling was used to measure microvascular density.Expression levels were compared according to clinicopathologic and patient parameters.RESULTS:Expression of Rho C m RNA showed a positive correlation with the protein level in esophageal squamous cell carcinoma,as well as with VEGF protein levels.Rho C m RNA expression was mainly located within the cytoplasm of the tumor cells,appearing as blue to purple particles by in situ hybridization.The differences in Rho C m RNA expression in esophageal squamous cell carcinoma,adjacent atypical hyperplasia and normal esophageal mucosa were significant(P < 0.05).The relative expression of Rho C m RNA in cancer tissues with lymph node metastasis was significantly higher than in the tissues without lymph node metastasis(P < 0.05).VEGF protein expression was consistent with microvascular density(t = 25.52,P < 0.05).Positive expression of VEGF protein in esophageal squamous cell carcinoma of different histologic gradings did not differ significantly.Positive expression of VEGF protein in carcinoma tissues with deep infiltration was significantly higher than in tissues with only superficial infiltration(P < 0.05).The positive expression of VEGF protein in cancer tissues with lymph node metastasis was significantly higher than in the tissues without lymph node metastasis(P < 0.05).CONCLUSION:Rho C protein may upregulate VEGF expression,thereby promoting tumor angiogenesis.Rho C m RNA and protein expression was correlated with metastasis. |
| doi_str_mv | 10.3748/wjg.v21.i3.905 |
| format | Article |
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Tian, Yan ; Yang, Jian-Pin ; Zhou, Jun ; Chen, Kui-Sheng</creator><creatorcontrib>Zhao, Zhi-Hua ; Tian, Yan ; Yang, Jian-Pin ; Zhou, Jun ; Chen, Kui-Sheng</creatorcontrib><description>AIM:To investigate the expression of Ras homolog(Rho)C,vascular endothelial growth factor(VEGF) and CD105 in esophageal squamous cell carcinoma.METHODS:Semi-quantitative reverse transcriptase polymerase chain reaction,in situ hybridization and immunohistochemical streptavidin-biotin- peroxidase methods were used to detect expression of Rho C m RNA and protein,and VEGF protein in 62 cases with esophageal squamous cell carcinoma,31 cases with adjacent atypical hyperplastic tissues,and 62 cases with normal esophageal mucosa.CD105 antibody labeling was used to measure microvascular density.Expression levels were compared according to clinicopathologic and patient parameters.RESULTS:Expression of Rho C m RNA showed a positive correlation with the protein level in esophageal squamous cell carcinoma,as well as with VEGF protein levels.Rho C m RNA expression was mainly located within the cytoplasm of the tumor cells,appearing as blue to purple particles by in situ hybridization.The differences in Rho C m RNA expression in esophageal squamous cell carcinoma,adjacent atypical hyperplasia and normal esophageal mucosa were significant(P &lt; 0.05).The relative expression of Rho C m RNA in cancer tissues with lymph node metastasis was significantly higher than in the tissues without lymph node metastasis(P &lt; 0.05).VEGF protein expression was consistent with microvascular density(t = 25.52,P &lt; 0.05).Positive expression of VEGF protein in esophageal squamous cell carcinoma of different histologic gradings did not differ significantly.Positive expression of VEGF protein in carcinoma tissues with deep infiltration was significantly higher than in tissues with only superficial infiltration(P &lt; 0.05).The positive expression of VEGF protein in cancer tissues with lymph node metastasis was significantly higher than in the tissues without lymph node metastasis(P &lt; 0.05).CONCLUSION:Rho C protein may upregulate VEGF expression,thereby promoting tumor angiogenesis.Rho C m RNA and protein expression was correlated with metastasis.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v21.i3.905</identifier><identifier>PMID: 25624724</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Inc</publisher><subject>Adult ; Aged ; Antigens, CD - analysis ; Carcinoma, Squamous Cell - blood supply ; Carcinoma, Squamous Cell - enzymology ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - pathology ; carcinoma;Gene ; Case Control Study ; Case-Control Studies ; cell ; Endoglin ; Esophageal ; Esophageal Neoplasms - blood supply ; Esophageal Neoplasms - enzymology ; Esophageal Neoplasms - genetics ; Esophageal Neoplasms - pathology ; Esophageal Squamous Cell Carcinoma ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; In Situ Hybridization ; Lymphatic Metastasis ; Male ; Microvessels - chemistry ; Microvessels - pathology ; Middle Aged ; Neoplasm Grading ; Neoplasm Invasiveness ; Neovascularization, Pathologic ; Receptors, Cell Surface - analysis ; Reverse Transcriptase Polymerase Chain Reaction ; rho GTP-Binding Proteins - analysis ; rho GTP-Binding Proteins - genetics ; rhoC GTP-Binding Protein ; RNA, Messenger - analysis ; silencing ; squamous ; Up-Regulation ; Vascular Endothelial Growth Factor A - analysis ; Vascular Endothelial Growth Factor A - genetics</subject><ispartof>World journal of gastroenterology : WJG, 2015-01, Vol.21 (3), p.905-912</ispartof><rights>The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. 2015</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-13976f9e73507546855ae5f284d1417360a2153d935e3a7f2e8a06353aa781773</citedby><cites>FETCH-LOGICAL-c500t-13976f9e73507546855ae5f284d1417360a2153d935e3a7f2e8a06353aa781773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299343/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299343/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25624724$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Zhi-Hua</creatorcontrib><creatorcontrib>Tian, Yan</creatorcontrib><creatorcontrib>Yang, Jian-Pin</creatorcontrib><creatorcontrib>Zhou, Jun</creatorcontrib><creatorcontrib>Chen, Kui-Sheng</creatorcontrib><title>RhoC,vascular endothelial growth factor and microvascular density in esophageal squamous cell carcinoma</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM:To investigate the expression of Ras homolog(Rho)C,vascular endothelial growth factor(VEGF) and CD105 in esophageal squamous cell carcinoma.METHODS:Semi-quantitative reverse transcriptase polymerase chain reaction,in situ hybridization and immunohistochemical streptavidin-biotin- peroxidase methods were used to detect expression of Rho C m RNA and protein,and VEGF protein in 62 cases with esophageal squamous cell carcinoma,31 cases with adjacent atypical hyperplastic tissues,and 62 cases with normal esophageal mucosa.CD105 antibody labeling was used to measure microvascular density.Expression levels were compared according to clinicopathologic and patient parameters.RESULTS:Expression of Rho C m RNA showed a positive correlation with the protein level in esophageal squamous cell carcinoma,as well as with VEGF protein levels.Rho C m RNA expression was mainly located within the cytoplasm of the tumor cells,appearing as blue to purple particles by in situ hybridization.The differences in Rho C m RNA expression in esophageal squamous cell carcinoma,adjacent atypical hyperplasia and normal esophageal mucosa were significant(P &lt; 0.05).The relative expression of Rho C m RNA in cancer tissues with lymph node metastasis was significantly higher than in the tissues without lymph node metastasis(P &lt; 0.05).VEGF protein expression was consistent with microvascular density(t = 25.52,P &lt; 0.05).Positive expression of VEGF protein in esophageal squamous cell carcinoma of different histologic gradings did not differ significantly.Positive expression of VEGF protein in carcinoma tissues with deep infiltration was significantly higher than in tissues with only superficial infiltration(P &lt; 0.05).The positive expression of VEGF protein in cancer tissues with lymph node metastasis was significantly higher than in the tissues without lymph node metastasis(P &lt; 0.05).CONCLUSION:Rho C protein may upregulate VEGF expression,thereby promoting tumor angiogenesis.Rho C m RNA and protein expression was correlated with metastasis.</description><subject>Adult</subject><subject>Aged</subject><subject>Antigens, CD - analysis</subject><subject>Carcinoma, Squamous Cell - blood supply</subject><subject>Carcinoma, Squamous Cell - enzymology</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>carcinoma;Gene</subject><subject>Case Control Study</subject><subject>Case-Control Studies</subject><subject>cell</subject><subject>Endoglin</subject><subject>Esophageal</subject><subject>Esophageal Neoplasms - blood supply</subject><subject>Esophageal Neoplasms - enzymology</subject><subject>Esophageal Neoplasms - genetics</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophageal Squamous Cell Carcinoma</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Microvessels - chemistry</subject><subject>Microvessels - pathology</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Invasiveness</subject><subject>Neovascularization, Pathologic</subject><subject>Receptors, Cell Surface - analysis</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>rho GTP-Binding Proteins - analysis</subject><subject>rho GTP-Binding Proteins - genetics</subject><subject>rhoC GTP-Binding Protein</subject><subject>RNA, Messenger - analysis</subject><subject>silencing</subject><subject>squamous</subject><subject>Up-Regulation</subject><subject>Vascular Endothelial Growth Factor A - analysis</subject><subject>Vascular Endothelial Growth Factor A - genetics</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1v1DAQxS0EokvhyhHlyIGktseO4wsSWpUPqVIl1J6tIXESV4m9aydb9b_HS5cV-DKW_Js3fvMIec9oBUo0V48PQ3XgrHJQaSpfkA3nTJe8EfQl2TBKVamBqwvyJqUHSjmA5K_JBZc1F4qLDRl-jmH76YCpXSeMhfVdWEY7OZyKIYbHZSx6bJcQC_RdMbs2hjPbWZ_c8lQ4X9gUdiMONnel_YpzWFPR2mkqWoyt82HGt-RVj1Oy7071ktx_vb7bfi9vbr_92H65KVtJ6VIy0KrutVUgqZKibqREK_vsp2OCKagpciah0yAtoOq5bZDWIAFRNUwpuCSfn3V366_Zdq31S8TJ7KKbMT6ZgM78_-LdaIZwMIJrDQKywMeTQAz71abFzC4dvaC32ZZhteSCCVA0o9UzmreSUrT9eQyj5piOyemYnI5xYHI6ueHDv58743_jyACcFMfgh73zw5nRtDkeLalohJYgGsn-3Gr4DcQpnPk</recordid><startdate>20150121</startdate><enddate>20150121</enddate><creator>Zhao, Zhi-Hua</creator><creator>Tian, Yan</creator><creator>Yang, Jian-Pin</creator><creator>Zhou, Jun</creator><creator>Chen, Kui-Sheng</creator><general>Baishideng Publishing Group Inc</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150121</creationdate><title>RhoC,vascular endothelial growth factor and microvascular density in esophageal squamous cell carcinoma</title><author>Zhao, Zhi-Hua ; Tian, Yan ; Yang, Jian-Pin ; Zhou, Jun ; Chen, Kui-Sheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-13976f9e73507546855ae5f284d1417360a2153d935e3a7f2e8a06353aa781773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antigens, CD - analysis</topic><topic>Carcinoma, Squamous Cell - blood supply</topic><topic>Carcinoma, Squamous Cell - enzymology</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>carcinoma;Gene</topic><topic>Case Control Study</topic><topic>Case-Control Studies</topic><topic>cell</topic><topic>Endoglin</topic><topic>Esophageal</topic><topic>Esophageal Neoplasms - blood supply</topic><topic>Esophageal Neoplasms - enzymology</topic><topic>Esophageal Neoplasms - genetics</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophageal Squamous Cell Carcinoma</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Microvessels - chemistry</topic><topic>Microvessels - pathology</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Invasiveness</topic><topic>Neovascularization, Pathologic</topic><topic>Receptors, Cell Surface - analysis</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>rho GTP-Binding Proteins - analysis</topic><topic>rho GTP-Binding Proteins - genetics</topic><topic>rhoC GTP-Binding Protein</topic><topic>RNA, Messenger - analysis</topic><topic>silencing</topic><topic>squamous</topic><topic>Up-Regulation</topic><topic>Vascular Endothelial Growth Factor A - analysis</topic><topic>Vascular Endothelial Growth Factor A - genetics</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Zhi-Hua</creatorcontrib><creatorcontrib>Tian, Yan</creatorcontrib><creatorcontrib>Yang, Jian-Pin</creatorcontrib><creatorcontrib>Zhou, Jun</creatorcontrib><creatorcontrib>Chen, Kui-Sheng</creatorcontrib><collection>维普_期刊</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>维普中文期刊数据库</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Zhi-Hua</au><au>Tian, Yan</au><au>Yang, Jian-Pin</au><au>Zhou, Jun</au><au>Chen, Kui-Sheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>RhoC,vascular endothelial growth factor and microvascular density in esophageal squamous cell carcinoma</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2015-01-21</date><risdate>2015</risdate><volume>21</volume><issue>3</issue><spage>905</spage><epage>912</epage><pages>905-912</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM:To investigate the expression of Ras homolog(Rho)C,vascular endothelial growth factor(VEGF) and CD105 in esophageal squamous cell carcinoma.METHODS:Semi-quantitative reverse transcriptase polymerase chain reaction,in situ hybridization and immunohistochemical streptavidin-biotin- peroxidase methods were used to detect expression of Rho C m RNA and protein,and VEGF protein in 62 cases with esophageal squamous cell carcinoma,31 cases with adjacent atypical hyperplastic tissues,and 62 cases with normal esophageal mucosa.CD105 antibody labeling was used to measure microvascular density.Expression levels were compared according to clinicopathologic and patient parameters.RESULTS:Expression of Rho C m RNA showed a positive correlation with the protein level in esophageal squamous cell carcinoma,as well as with VEGF protein levels.Rho C m RNA expression was mainly located within the cytoplasm of the tumor cells,appearing as blue to purple particles by in situ hybridization.The differences in Rho C m RNA expression in esophageal squamous cell carcinoma,adjacent atypical hyperplasia and normal esophageal mucosa were significant(P &lt; 0.05).The relative expression of Rho C m RNA in cancer tissues with lymph node metastasis was significantly higher than in the tissues without lymph node metastasis(P &lt; 0.05).VEGF protein expression was consistent with microvascular density(t = 25.52,P &lt; 0.05).Positive expression of VEGF protein in esophageal squamous cell carcinoma of different histologic gradings did not differ significantly.Positive expression of VEGF protein in carcinoma tissues with deep infiltration was significantly higher than in tissues with only superficial infiltration(P &lt; 0.05).The positive expression of VEGF protein in cancer tissues with lymph node metastasis was significantly higher than in the tissues without lymph node metastasis(P &lt; 0.05).CONCLUSION:Rho C protein may upregulate VEGF expression,thereby promoting tumor angiogenesis.Rho C m RNA and protein expression was correlated with metastasis.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Inc</pub><pmid>25624724</pmid><doi>10.3748/wjg.v21.i3.905</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Antigens, CD - analysis Carcinoma, Squamous Cell - blood supply Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology carcinoma Gene Case Control Study Case-Control Studies cell Endoglin Esophageal Esophageal Neoplasms - blood supply Esophageal Neoplasms - enzymology Esophageal Neoplasms - genetics Esophageal Neoplasms - pathology Esophageal Squamous Cell Carcinoma Female Gene Expression Regulation, Neoplastic Humans Immunohistochemistry In Situ Hybridization Lymphatic Metastasis Male Microvessels - chemistry Microvessels - pathology Middle Aged Neoplasm Grading Neoplasm Invasiveness Neovascularization, Pathologic Receptors, Cell Surface - analysis Reverse Transcriptase Polymerase Chain Reaction rho GTP-Binding Proteins - analysis rho GTP-Binding Proteins - genetics rhoC GTP-Binding Protein RNA, Messenger - analysis silencing squamous Up-Regulation Vascular Endothelial Growth Factor A - analysis Vascular Endothelial Growth Factor A - genetics |
| title | RhoC,vascular endothelial growth factor and microvascular density in esophageal squamous cell carcinoma |
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