Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: Role for omega-3 epoxides

Significance Our study demonstrates that stabilization of cytochrome P-450 epoxides derived from omega-3 polyunsaturated fatty acids through inhibition of the inactivating enzyme soluble epoxide hydrolase (sEH) exerts beneficial actions in counteracting metabolic disorders associated with obesity. I...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-01, Vol.112 (2), p.536-541
Hauptverfasser:	López-Vicario, Cristina, Alcaraz-Quiles, José, García-Alonso, Verónica, Rius, Bibiana, Hwang, Sung H., Titos, Esther, Lopategi, Aritz, Hammock, Bruce D., Arroyo, Vicente, Clària, Joan
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Adipose Tissue - drug effects Adipose Tissue - metabolism Adipose Tissue - pathology Adipose tissues Animals Autofàgia Autophagy Autophagy - physiology Benzoates - pharmacology Biological Sciences Cadherins - genetics Cadherins - metabolism Cytochrome P-450 CYP1A1 - metabolism Cytochrome P-450 CYP2E1 - metabolism Cytochrome P-450 Enzyme System - metabolism Enzyme Inhibitors - pharmacology Epoxide Hydrolases - antagonists & inhibitors Epoxy Compounds - metabolism Fatty Acid Desaturases - genetics Fatty Acid Desaturases - metabolism Fatty Acids, Omega-3 - metabolism Female Inflamació Inflammation Inflammation - metabolism Inflammation - pathology Liver Liver - drug effects Liver - metabolism Liver - pathology Liver diseases Malalties del fetge Male Mice Mice, Inbred C57BL Mice, Mutant Strains Mice, Transgenic Obesitat Obesity Obesity - metabolism Obesity - pathology Omega-3 fatty acids Phenylurea Compounds - pharmacology Teixit adipós Tissues Unsaturated fatty acids Àcids grassos insaturats Àcids grassos omega-3
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