Progerin expression disrupts critical adult stem cell functions involved in tissue repair

Vascular disease is one of the leading causes of death worldwide. Vascular repair, essential for tissue maintenance, is critically reduced during vascular disease and aging. Efficient vascular repair requires functional adult stem cells unimpaired by aging or mutation. One protein candidate for redu...

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2014-12, Vol.6 (12), p.1049-1063
Hauptverfasser:	Pacheco, Laurin Marie, Gomez, Lourdes Adriana, Dias, Janice, Ziebarth, Noel M, Howard, Guy A, Schiller, Paul C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Adult Stem Cells - drug effects Adult Stem Cells - enzymology Adult Stem Cells - metabolism Adult Stem Cells - pathology Aged Cell Membrane - metabolism Cell Membrane - pathology Cell Movement Cell Proliferation Child Enzyme Inhibitors - pharmacology Farnesyltranstransferase - antagonists & inhibitors Farnesyltranstransferase - metabolism Gene Expression Regulation HEK293 Cells Humans Lamin Type A Male Membrane Fluidity Mesenchymal Stem Cells - drug effects Mesenchymal Stem Cells - enzymology Mesenchymal Stem Cells - metabolism Mesenchymal Stem Cells - pathology Middle Aged Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein Precursors - genetics Protein Precursors - metabolism Regeneration - drug effects Research Paper RNA, Messenger - metabolism Signal Transduction Time Factors Transfection Young Adult
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