Prostacyclin Regulates Bone Growth via the Epac/Rap1 Pathway

Prostaglandins, particularly PGE2, are important to adult bone and joint health, but how prostaglandins act on growth plate cartilage to affect bone growth is unclear. We show that growth plate cartilage is distinct from articular cartilage with respect to cyclooxygenase (COX)-2 mRNA expression; alt...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Endocrinology (Philadelphia) 2015-02, Vol.156 (2), p.499-510
Hauptverfasser:	Hutchison, Michele R, White, Perrin C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-inflammatory agents Anti-Inflammatory Agents, Non-Steroidal Bone Development Bone growth Cartilage Cartilage (articular) Cattle Celecoxib Cell proliferation Cells, Cultured Chondrocytes Chondrocytes - enzymology Cyclic AMP Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Dwarfism Epoprostenol - secretion Explants Female Forskolin Gene expression General Endocrinology Growth plate Growth Plate - drug effects Growth Plate - enzymology Guanine Nucleotide Exchange Factors - metabolism Humans Iloprost Insulin-like growth factor I Insulin-Like Growth Factor I - metabolism Male Mice Mice, Inbred C57BL Nonsteroidal anti-inflammatory drugs Prostacyclin Prostaglandin D2 Prostaglandin E2 Prostaglandins Prostaglandins I - physiology Pyrazoles rap1 GTP-Binding Proteins - metabolism Rap1 protein Signal Transduction Sulfonamides
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!