The functional polymorphism rs73598374:G>A (p.Asp8Asn) of the ADA gene is associated with telomerase activity and leukocyte telomere length

Recent evidence demonstrated a relevant role of adenosine deaminase (ADA) in replicative senescence of T cells through its capacity to modulate telomerase activity (TA). Herein, we tested the impact of the functional polymorphism ADA rs73598374:G>A (c.22G>A, p.Asp8Asn) on telomere biology, by...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of human genetics : EJHG 2015-02, Vol.23 (2), p.267-270
Hauptverfasser:	Concetti, Fabio, Carpi, Francesco M, Nabissi, Massimo, Picciolini, Matteo, Santoni, Giorgio, Napolioni, Valerio
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome ADA gene Adenosine Adenosine deaminase Adenosine Deaminase - genetics Adenosine Deaminase - metabolism Adult Age Aged Aged, 80 and over Aging AIDS Biology Cell culture Chromosomes Female Gene polymorphism Genetics Genomics Genotype & phenotype Humans Immune system Immunology Leukocytes - metabolism Lymphocytes Lymphocytes T Male Polymorphism, Single Nucleotide Senescence Short Report Telomerase Telomerase - metabolism Telomere Homeostasis - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!