The regulation of RhoA at focal adhesions by StarD13 is important for astrocytoma cell motility

Malignant astrocytomas are highly invasive into adjacent and distant regions of the normal brain. Rho GTPases are small monomeric G proteins that play important roles in cytoskeleton rearrangement, cell motility, and tumor invasion. In the present study, we show that the knock down of StarD13, a GTP...

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Veröffentlicht in:	Experimental cell research 2014-02, Vol.321 (2), p.109-122
Hauptverfasser:	Khalil, Bassem D., Hanna, Samer, Saykali, Bechara A., El-Sitt, Sally, Nasrallah, Anita, Marston, Daniel, El-Sabban, Marwan, Hahn, Klaus M., Symons, Marc, El-Sibai, Mirvat
Format:	Artikel
Sprache:	eng
Schlagworte:	Astrocytoma Astrocytoma - genetics Astrocytoma - metabolism Astrocytoma - pathology Brain cancer Cell adhesion & migration Cell Adhesion - drug effects Cell Adhesion - genetics Cell motility Cell Movement - drug effects Cell Movement - genetics Focal Adhesions - drug effects Focal Adhesions - genetics Focal Adhesions - metabolism Gene Expression Regulation, Neoplastic - drug effects Gene Knockdown Techniques Humans Protein expression Rac RhoA rhoA GTP-Binding Protein - antagonists & inhibitors rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - metabolism RNA, Small Interfering - pharmacology StarD13 Tissue Distribution - drug effects Tissue Distribution - genetics Tumor Cells, Cultured Tumor Suppressor Proteins - antagonists & inhibitors Tumor Suppressor Proteins - physiology
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