Insulin resistance predicts brain amyloid deposition in late middle-aged adults

Abstract Background Insulin resistance (IR) increases Alzheimer's disease (AD) risk. IR is related to greater amyloid burden post-mortem and increased deposition within areas affected by early AD. No studies have examined if IR is associated with an in vivo index of amyloid in the human brain i...

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Veröffentlicht in:	Alzheimer's & dementia 2015-05, Vol.11 (5), p.504-510.e1
Hauptverfasser:	Willette, Auriel A, Johnson, Sterling C, Birdsill, Alex C, Sager, Mark A, Christian, Bradley, Baker, Laura D, Craft, Suzanne, Oh, Jennifer, Statz, Eric, Hermann, Bruce P, Jonaitis, Erin M, Koscik, Rebecca L, La Rue, Asenath, Asthana, Sanjay, Bendlin, Barbara B
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer's disease Amyloid Amyloid - metabolism Aniline Compounds - pharmacokinetics Apolipoproteins E - genetics Body Mass Index Brain - diagnostic imaging Brain - metabolism Cognitively normal Female Humans Hyperglycemia - complications Imaging, Three-Dimensional Insulin Resistance Magnetic Resonance Imaging Male Mental Status Schedule Middle Aged Neurology PiB Positron-Emission Tomography Predictive Value of Tests Prefrontal Thiazoles - pharmacokinetics
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