Broadening of the red blood cell distribution width is associated with increased severity of illness in patients with sepsis
Sepsis is a pro-inflammatory state caused by systemic infection. As sepsis progresses, multiple organ systems become affected with subsequent increase in mortality. Elevated red cell distribution width (RDW) has been seen with changes of other inflammatory markers and thus could potentially serve as...
Gespeichert in:
| Veröffentlicht in: | International Journal of Critical Illness and Injury Science 2014-10, Vol.4 (4), p.278-282 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 282 |
|---|---|
| container_issue | 4 |
| container_start_page | 278 |
| container_title | International Journal of Critical Illness and Injury Science |
| container_volume | 4 |
| creator | Mahmood, Nader A Mathew, Jacob Kang, Balwinder DeBari, Vincent A Khan, Muhammad Anees |
| description | Sepsis is a pro-inflammatory state caused by systemic infection. As sepsis progresses, multiple organ systems become affected with subsequent increase in mortality. Elevated red cell distribution width (RDW) has been seen with changes of other inflammatory markers and thus could potentially serve as a means of assessing sepsis severity. In this study, we examine the association of RDW with APACHE II score and in-hospital mortality.
We conducted a retrospective study involving a cohort of patients with sepsis. The study period spanned 2 years with a cohort of 349 patients. Data were collected to determine if RDW is associated with APACHE II scores and in-hospital mortality in this cohort.
RDW correlated weakly (r s = 0.27), but significantly (P < 0.0001) with APACHE II scores; coefficient of determination (r (2) = 0.09). The odds ratios for the association of RDW with APACHE II were calculated over the RDW range 12-20% at a dichotomized level of APACHE II, i.e., |
| doi_str_mv | 10.4103/2229-5151.147518 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4296328</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>25625057</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2418-fb80b6fb93f63d3423183171837ceee6d9a4a56faf3af9cf17ac41d99d3d6803</originalsourceid><addsrcrecordid>eNpVUctKAzEUDaLYUrt3JfmBqXnNayNo8QUFN92HTB5tZDopudNKwY83Q2vRLJJ7c-45NzkXoVtKZoISfs8Yq7Oc5nRGRZnT6gKNGeM0ywkRl0N8gkdoCvBJ0hJ1VVJyjUYsL1hO8nKMvp9iUMZ2vlvh4HC_tjhag5s2BIO1bVtsPPTRN7vehw5_edOvsQesAIL2qk-1X3646nS0ClIKdm-j7w-DnG_bzgIkFG9V723Xw7Ec7BY83KArp1qw09M5QcuX5-X8LVt8vL7PHxeZZoJWmWsq0hSuqbkruOEifbLitExbqa21hamVUHnhlOPK1drRUmlBTV0bboqK8Al6OMpud83GGp2eEVUrt9FvVDzIoLz8j3R-LVdhLwWrC86qJECOAjoGgGjdmUuJHGYhB7PlYLY8ziJR7v72PBN-nec_X4qINg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Broadening of the red blood cell distribution width is associated with increased severity of illness in patients with sepsis</title><source>PubMed Central Open Access</source><source>Medknow Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Mahmood, Nader A ; Mathew, Jacob ; Kang, Balwinder ; DeBari, Vincent A ; Khan, Muhammad Anees</creator><creatorcontrib>Mahmood, Nader A ; Mathew, Jacob ; Kang, Balwinder ; DeBari, Vincent A ; Khan, Muhammad Anees</creatorcontrib><description>Sepsis is a pro-inflammatory state caused by systemic infection. As sepsis progresses, multiple organ systems become affected with subsequent increase in mortality. Elevated red cell distribution width (RDW) has been seen with changes of other inflammatory markers and thus could potentially serve as a means of assessing sepsis severity. In this study, we examine the association of RDW with APACHE II score and in-hospital mortality.
We conducted a retrospective study involving a cohort of patients with sepsis. The study period spanned 2 years with a cohort of 349 patients. Data were collected to determine if RDW is associated with APACHE II scores and in-hospital mortality in this cohort.
RDW correlated weakly (r s = 0.27), but significantly (P < 0.0001) with APACHE II scores; coefficient of determination (r (2) = 0.09). The odds ratios for the association of RDW with APACHE II were calculated over the RDW range 12-20% at a dichotomized level of APACHE II, i.e., <15 and ≥15. At a RDW ≥16%, multivariate analysis including all potential confounders indicated that RDW was independently associated with an APACHE II score of ≥15. Similarly, mortality was associated with RDW ≥16%.
A prognostic biomarker for sepsis in the form of a routine blood test may be of considerable clinical utility. The results of our study suggest that RDW may have value in differentiating between more severe and less severe cases of sepsis. Future studies with larger samples are needed to confirm these findings.</description><identifier>ISSN: 2229-5151</identifier><identifier>EISSN: 2231-5004</identifier><identifier>DOI: 10.4103/2229-5151.147518</identifier><identifier>PMID: 25625057</identifier><language>eng</language><publisher>India: Medknow Publications & Media Pvt Ltd</publisher><subject>Original</subject><ispartof>International Journal of Critical Illness and Injury Science, 2014-10, Vol.4 (4), p.278-282</ispartof><rights>Copyright: © International Journal of Critical Illness and Injury Science 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2418-fb80b6fb93f63d3423183171837ceee6d9a4a56faf3af9cf17ac41d99d3d6803</citedby><cites>FETCH-LOGICAL-c2418-fb80b6fb93f63d3423183171837ceee6d9a4a56faf3af9cf17ac41d99d3d6803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296328/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296328/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25625057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mahmood, Nader A</creatorcontrib><creatorcontrib>Mathew, Jacob</creatorcontrib><creatorcontrib>Kang, Balwinder</creatorcontrib><creatorcontrib>DeBari, Vincent A</creatorcontrib><creatorcontrib>Khan, Muhammad Anees</creatorcontrib><title>Broadening of the red blood cell distribution width is associated with increased severity of illness in patients with sepsis</title><title>International Journal of Critical Illness and Injury Science</title><addtitle>Int J Crit Illn Inj Sci</addtitle><description>Sepsis is a pro-inflammatory state caused by systemic infection. As sepsis progresses, multiple organ systems become affected with subsequent increase in mortality. Elevated red cell distribution width (RDW) has been seen with changes of other inflammatory markers and thus could potentially serve as a means of assessing sepsis severity. In this study, we examine the association of RDW with APACHE II score and in-hospital mortality.
We conducted a retrospective study involving a cohort of patients with sepsis. The study period spanned 2 years with a cohort of 349 patients. Data were collected to determine if RDW is associated with APACHE II scores and in-hospital mortality in this cohort.
RDW correlated weakly (r s = 0.27), but significantly (P < 0.0001) with APACHE II scores; coefficient of determination (r (2) = 0.09). The odds ratios for the association of RDW with APACHE II were calculated over the RDW range 12-20% at a dichotomized level of APACHE II, i.e., <15 and ≥15. At a RDW ≥16%, multivariate analysis including all potential confounders indicated that RDW was independently associated with an APACHE II score of ≥15. Similarly, mortality was associated with RDW ≥16%.
A prognostic biomarker for sepsis in the form of a routine blood test may be of considerable clinical utility. The results of our study suggest that RDW may have value in differentiating between more severe and less severe cases of sepsis. Future studies with larger samples are needed to confirm these findings.</description><subject>Original</subject><issn>2229-5151</issn><issn>2231-5004</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNpVUctKAzEUDaLYUrt3JfmBqXnNayNo8QUFN92HTB5tZDopudNKwY83Q2vRLJJ7c-45NzkXoVtKZoISfs8Yq7Oc5nRGRZnT6gKNGeM0ywkRl0N8gkdoCvBJ0hJ1VVJyjUYsL1hO8nKMvp9iUMZ2vlvh4HC_tjhag5s2BIO1bVtsPPTRN7vehw5_edOvsQesAIL2qk-1X3646nS0ClIKdm-j7w-DnG_bzgIkFG9V723Xw7Ec7BY83KArp1qw09M5QcuX5-X8LVt8vL7PHxeZZoJWmWsq0hSuqbkruOEifbLitExbqa21hamVUHnhlOPK1drRUmlBTV0bboqK8Al6OMpud83GGp2eEVUrt9FvVDzIoLz8j3R-LVdhLwWrC86qJECOAjoGgGjdmUuJHGYhB7PlYLY8ziJR7v72PBN-nec_X4qINg</recordid><startdate>201410</startdate><enddate>201410</enddate><creator>Mahmood, Nader A</creator><creator>Mathew, Jacob</creator><creator>Kang, Balwinder</creator><creator>DeBari, Vincent A</creator><creator>Khan, Muhammad Anees</creator><general>Medknow Publications & Media Pvt Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>201410</creationdate><title>Broadening of the red blood cell distribution width is associated with increased severity of illness in patients with sepsis</title><author>Mahmood, Nader A ; Mathew, Jacob ; Kang, Balwinder ; DeBari, Vincent A ; Khan, Muhammad Anees</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2418-fb80b6fb93f63d3423183171837ceee6d9a4a56faf3af9cf17ac41d99d3d6803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Original</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mahmood, Nader A</creatorcontrib><creatorcontrib>Mathew, Jacob</creatorcontrib><creatorcontrib>Kang, Balwinder</creatorcontrib><creatorcontrib>DeBari, Vincent A</creatorcontrib><creatorcontrib>Khan, Muhammad Anees</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International Journal of Critical Illness and Injury Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mahmood, Nader A</au><au>Mathew, Jacob</au><au>Kang, Balwinder</au><au>DeBari, Vincent A</au><au>Khan, Muhammad Anees</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Broadening of the red blood cell distribution width is associated with increased severity of illness in patients with sepsis</atitle><jtitle>International Journal of Critical Illness and Injury Science</jtitle><addtitle>Int J Crit Illn Inj Sci</addtitle><date>2014-10</date><risdate>2014</risdate><volume>4</volume><issue>4</issue><spage>278</spage><epage>282</epage><pages>278-282</pages><issn>2229-5151</issn><eissn>2231-5004</eissn><abstract>Sepsis is a pro-inflammatory state caused by systemic infection. As sepsis progresses, multiple organ systems become affected with subsequent increase in mortality. Elevated red cell distribution width (RDW) has been seen with changes of other inflammatory markers and thus could potentially serve as a means of assessing sepsis severity. In this study, we examine the association of RDW with APACHE II score and in-hospital mortality.
We conducted a retrospective study involving a cohort of patients with sepsis. The study period spanned 2 years with a cohort of 349 patients. Data were collected to determine if RDW is associated with APACHE II scores and in-hospital mortality in this cohort.
RDW correlated weakly (r s = 0.27), but significantly (P < 0.0001) with APACHE II scores; coefficient of determination (r (2) = 0.09). The odds ratios for the association of RDW with APACHE II were calculated over the RDW range 12-20% at a dichotomized level of APACHE II, i.e., <15 and ≥15. At a RDW ≥16%, multivariate analysis including all potential confounders indicated that RDW was independently associated with an APACHE II score of ≥15. Similarly, mortality was associated with RDW ≥16%.
A prognostic biomarker for sepsis in the form of a routine blood test may be of considerable clinical utility. The results of our study suggest that RDW may have value in differentiating between more severe and less severe cases of sepsis. Future studies with larger samples are needed to confirm these findings.</abstract><cop>India</cop><pub>Medknow Publications & Media Pvt Ltd</pub><pmid>25625057</pmid><doi>10.4103/2229-5151.147518</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2229-5151 |
| ispartof | International Journal of Critical Illness and Injury Science, 2014-10, Vol.4 (4), p.278-282 |
| issn | 2229-5151 2231-5004 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4296328 |
| source | PubMed Central Open Access; Medknow Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Original |
| title | Broadening of the red blood cell distribution width is associated with increased severity of illness in patients with sepsis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T03%3A57%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Broadening%20of%20the%20red%20blood%20cell%20distribution%20width%20is%20associated%20with%20increased%20severity%20of%20illness%20in%20patients%20with%20sepsis&rft.jtitle=International%20Journal%20of%20Critical%20Illness%20and%20Injury%20Science&rft.au=Mahmood,%20Nader%20A&rft.date=2014-10&rft.volume=4&rft.issue=4&rft.spage=278&rft.epage=282&rft.pages=278-282&rft.issn=2229-5151&rft.eissn=2231-5004&rft_id=info:doi/10.4103/2229-5151.147518&rft_dat=%3Cpubmed_cross%3E25625057%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/25625057&rfr_iscdi=true |