A novel IgM–H-Ficolin complement pathway to attack allogenic cancer cells in vitro

The pentameric serum IgMs are critical to immune defense and surveillance through cytotoxicity against microbes and nascent cancer cells. Ficolins, a group of oligomeric lectins with an overall structure similar to C1q and mannose-binding lectin (MBL) participate in microbe infection and apoptotic c...

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Veröffentlicht in:	Scientific reports 2015-01, Vol.5 (1), p.7824-7824, Article 7824
Hauptverfasser:	Lei, Xiaoying, Liu, Chaoxu, Azadzoi, Kazem, Li, Cuiling, Lu, Fan, Xiang, An, Sun, Jianbin, Guo, Yanhai, Zhao, Qingchuan, Yan, Zhen, Yang, Jinghua
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 14/19 14/28 14/34 631/250 631/67 82/29 Adult Aged Apoptosis Cancer Cell Line, Tumor Complement Activation Complement component C1q Complement System Proteins - metabolism Cytotoxicity Female Ficolins Glycoproteins - chemistry Glycoproteins - immunology Glycoproteins - metabolism HT29 Cells Human populations Humanities and Social Sciences Humans Immune clearance Immune system Immunoglobulin M Immunoglobulin M - chemistry Immunoglobulin M - immunology Immunoglobulin M - metabolism Immunosurveillance Lectins - chemistry Lectins - immunology Lectins - metabolism Male Mannose Mannose-binding lectin MCF-7 Cells Microscopy, Electron, Transmission Microscopy, Fluorescence Middle Aged multidisciplinary Opsonophagocytosis Protein Binding Science Serum - immunology Serum - metabolism
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