Synthesis and Structural Activity Relationship Study of Antitubercular Carboxamides

The unusual structure and chemical composition of the mycobacterial cell wall, the tedious duration of therapy, and resistance developed by the microorganism have made the recurrence of the disease multidrug resistance and extensive or extreme drug resistance. The prevalence of tuberculosis in syner...

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Veröffentlicht in:International Journal of Medicinal Chemistry (Online) 2014-01, Vol.2014, p.614808-18
Hauptverfasser: Ugwu, D. I., Ezema, B. E., Eze, F. U., Ugwuja, D. I.
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container_end_page 18
container_issue
container_start_page 614808
container_title International Journal of Medicinal Chemistry (Online)
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creator Ugwu, D. I.
Ezema, B. E.
Eze, F. U.
Ugwuja, D. I.
description The unusual structure and chemical composition of the mycobacterial cell wall, the tedious duration of therapy, and resistance developed by the microorganism have made the recurrence of the disease multidrug resistance and extensive or extreme drug resistance. The prevalence of tuberculosis in synergy with HIV/AIDS epidemic augments the risk of developing the disease by 100-fold. The need to synthesize new drugs that will shorten the total duration of effective treatment and/or significantly reduce the dosage taken under DOTS supervision, improve on the treatment of multidrug-resistant tuberculosis which defies the treatment with isoniazid and rifampicin, and provide effective treatment for latent TB infections which is essential for eliminating tuberculosis prompted this review. In this review, we considered the synthesis and structure activity relationship study of carboxamide derivatives with antitubercular potential.
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title Synthesis and Structural Activity Relationship Study of Antitubercular Carboxamides
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