Fluvastatin Upregulates the α 1C Subunit of CaV1.2 Channel Expression in Vascular Smooth Muscle Cells via RhoA and ERK/p38 MAPK Pathways

Abnormal phenotypic switch of vascular smooth muscle cell (VSMC) is a hallmark of vascular disorders such as atherosclerosis and restenosis. And this process has been related to remodeling of L-type calcium channel (LTCC). We attempted to investigate whether fluvastatin has any effect on VSMC prolif...

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Veröffentlicht in:	Disease markers 2014-01, Vol.2014 (2014), p.1-9
Hauptverfasser:	Xu, Chang-Sheng, Xie, Hong, Lin, Zhi-Hong, Han, Ying, Ouyang, Qiufang, Xie, Liang-Di
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arteriosclerosis Atherosclerosis Calcium channels Calcium channels (L-type) Calcium channels (voltage-gated) Calcium Channels, L-Type - genetics Calcium Channels, L-Type - metabolism Cell culture Cell cycle Cell Cycle Checkpoints Cell growth Cell Proliferation Extracellular signal-regulated kinase Fatty Acids, Monounsaturated - pharmacology Flow cytometry Flow mapping Fluvastatin G1 phase Gene expression Genotype & phenotype Growth factors Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Indoles - pharmacology Kinases MAP kinase MAP Kinase Signaling System Muscle contraction Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Osteopontin Phenotypes Platelet-Derived Growth Factor - physiology Platelet-derived growth factor BB Protein expression Protein Transport - drug effects Proteins Rats, Inbred SHR Restenosis rhoA GTP-Binding Protein - metabolism RhoA protein Rocks Smooth muscle Thymidine Up-Regulation - drug effects Vascular diseases Western blotting
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