CCR5 receptor antagonists block metastasis to bone of v-Src oncogene-transformed metastatic prostate cancer cell lines

Src family kinases (SFK) integrate signal transduction for multiple receptors, regulating cellular proliferation, invasion, and metastasis in human cancer. Although Src is rarely mutated in human prostate cancer, SFK activity is increased in the majority of human prostate cancers. To determine the m...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2014-12, Vol.74 (23), p.7103-7114
Hauptverfasser:	Sicoli, Daniela, Jiao, Xuanmao, Ju, Xiaoming, Velasco-Velazquez, Marco, Ertel, Adam, Addya, Sankar, Li, Zhiping, Andò, Sebastiano, Fatatis, Alessandro, Paudyal, Bishnuhari, Cristofanilli, Massimo, Thakur, Mathew L, Lisanti, Michael P, Pestell, Richard G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Neoplasms - metabolism Bone Neoplasms - prevention & control Bone Neoplasms - secondary Brain Neoplasms - metabolism Brain Neoplasms - prevention & control Brain Neoplasms - secondary CCR5 Receptor Antagonists - pharmacology Cell Line, Transformed Cell Line, Tumor Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - pathology Epithelium - drug effects Epithelium - metabolism Epithelium - pathology Gene Expression Profiling - methods Genes, src Humans Lentivirus Male Mice Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Protein Kinase Inhibitors - pharmacology Receptors, CCR5 - genetics Receptors, CCR5 - metabolism Retroviridae src-Family Kinases - genetics src-Family Kinases - metabolism
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