Henle fiber layer phase retardation changes associated with age-related macular degeneration
To quantify and compare phase retardation amplitude and regularity associated with the Henle fiber layer (HFL) between nonexudative AMD patients and age-matched controls using scanning laser polarimetry (SLP) imaging. A scanning laser polarimeter was used to collect 15 × 15° macular-centered images...
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Veröffentlicht in: | Investigative ophthalmology & visual science 2015-01, Vol.56 (1), p.284-290 |
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creator | VanNasdale, Dean A Elsner, Ann E Peabody, Todd D Kohne, Kimberly D Malinovsky, Victor E Haggerty, Bryan P Weber, Anke Clark, Christopher A Burns, Stephen A |
description | To quantify and compare phase retardation amplitude and regularity associated with the Henle fiber layer (HFL) between nonexudative AMD patients and age-matched controls using scanning laser polarimetry (SLP) imaging.
A scanning laser polarimeter was used to collect 15 × 15° macular-centered images in 25 patients with nonexudative AMD and 25 age-matched controls. Raw image data were used to compute macular phase retardation maps associated with the HFL. Consecutive, annular regions of interest from 0.5 to 3.0° eccentricity, centered on the fovea, were used to generate intensity profiles from phase retardation data and analyzed with two complementary techniques: a normalized second harmonic frequency (2f) of the fast Fourier Transform (FFT) analysis and a curve fitting analysis using a 2f sine function. Paired t-tests were used to compare the normalized 2f FFT magnitude at each eccentricity between the two groups, the eccentricity that yielded the maximum normalized 2f FFT between paired individuals across the two groups, and curve fitting RMS error at each eccentricity between the two groups.
Normalized 2f FFT components were lower in the AMD group at each eccentricity, with no difference between the two groups in the maximum normalized 2f FFT component eccentricity. The root-mean-square (RMS) error from curve fitting was significantly higher in the AMD group.
Phase retardation changes in the central macula indicate loss and/or structural alterations to central cone photoreceptors in nonexudative AMD patients. Scanning laser polarimetry imaging is a noninvasive method for quantifying cone photoreceptor changes associated with central macular disease. |
doi_str_mv | 10.1167/iovs.14-14459 |
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A scanning laser polarimeter was used to collect 15 × 15° macular-centered images in 25 patients with nonexudative AMD and 25 age-matched controls. Raw image data were used to compute macular phase retardation maps associated with the HFL. Consecutive, annular regions of interest from 0.5 to 3.0° eccentricity, centered on the fovea, were used to generate intensity profiles from phase retardation data and analyzed with two complementary techniques: a normalized second harmonic frequency (2f) of the fast Fourier Transform (FFT) analysis and a curve fitting analysis using a 2f sine function. Paired t-tests were used to compare the normalized 2f FFT magnitude at each eccentricity between the two groups, the eccentricity that yielded the maximum normalized 2f FFT between paired individuals across the two groups, and curve fitting RMS error at each eccentricity between the two groups.
Normalized 2f FFT components were lower in the AMD group at each eccentricity, with no difference between the two groups in the maximum normalized 2f FFT component eccentricity. The root-mean-square (RMS) error from curve fitting was significantly higher in the AMD group.
Phase retardation changes in the central macula indicate loss and/or structural alterations to central cone photoreceptors in nonexudative AMD patients. Scanning laser polarimetry imaging is a noninvasive method for quantifying cone photoreceptor changes associated with central macular disease.</description><identifier>ISSN: 0146-0404</identifier><identifier>EISSN: 1552-5783</identifier><identifier>DOI: 10.1167/iovs.14-14459</identifier><identifier>PMID: 25525166</identifier><language>eng</language><publisher>United States: The Association for Research in Vision and Ophthalmology</publisher><subject>Aged ; Aged, 80 and over ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Macula Lutea - pathology ; Macular Degeneration - diagnosis ; Male ; Middle Aged ; Retinal Cone Photoreceptor Cells - pathology ; Retinal Ganglion Cells - pathology ; Scanning Laser Polarimetry</subject><ispartof>Investigative ophthalmology & visual science, 2015-01, Vol.56 (1), p.284-290</ispartof><rights>Copyright 2015 The Association for Research in Vision and Ophthalmology, Inc.</rights><rights>Copyright 2015 The Association for Research in Vision and Ophthalmology, Inc. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-6a74a2ca6c2ee30e1ce906a7455f23261ad11654b81601d587f8c76f497c5ac53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294289/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294289/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25525166$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VanNasdale, Dean A</creatorcontrib><creatorcontrib>Elsner, Ann E</creatorcontrib><creatorcontrib>Peabody, Todd D</creatorcontrib><creatorcontrib>Kohne, Kimberly D</creatorcontrib><creatorcontrib>Malinovsky, Victor E</creatorcontrib><creatorcontrib>Haggerty, Bryan P</creatorcontrib><creatorcontrib>Weber, Anke</creatorcontrib><creatorcontrib>Clark, Christopher A</creatorcontrib><creatorcontrib>Burns, Stephen A</creatorcontrib><title>Henle fiber layer phase retardation changes associated with age-related macular degeneration</title><title>Investigative ophthalmology & visual science</title><addtitle>Invest Ophthalmol Vis Sci</addtitle><description>To quantify and compare phase retardation amplitude and regularity associated with the Henle fiber layer (HFL) between nonexudative AMD patients and age-matched controls using scanning laser polarimetry (SLP) imaging.
A scanning laser polarimeter was used to collect 15 × 15° macular-centered images in 25 patients with nonexudative AMD and 25 age-matched controls. Raw image data were used to compute macular phase retardation maps associated with the HFL. Consecutive, annular regions of interest from 0.5 to 3.0° eccentricity, centered on the fovea, were used to generate intensity profiles from phase retardation data and analyzed with two complementary techniques: a normalized second harmonic frequency (2f) of the fast Fourier Transform (FFT) analysis and a curve fitting analysis using a 2f sine function. Paired t-tests were used to compare the normalized 2f FFT magnitude at each eccentricity between the two groups, the eccentricity that yielded the maximum normalized 2f FFT between paired individuals across the two groups, and curve fitting RMS error at each eccentricity between the two groups.
Normalized 2f FFT components were lower in the AMD group at each eccentricity, with no difference between the two groups in the maximum normalized 2f FFT component eccentricity. The root-mean-square (RMS) error from curve fitting was significantly higher in the AMD group.
Phase retardation changes in the central macula indicate loss and/or structural alterations to central cone photoreceptors in nonexudative AMD patients. Scanning laser polarimetry imaging is a noninvasive method for quantifying cone photoreceptor changes associated with central macular disease.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Macula Lutea - pathology</subject><subject>Macular Degeneration - diagnosis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retinal Cone Photoreceptor Cells - pathology</subject><subject>Retinal Ganglion Cells - pathology</subject><subject>Scanning Laser Polarimetry</subject><issn>0146-0404</issn><issn>1552-5783</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1PwzAMhiMEYmNw5Ip65NKRpEnaXpDQBAxpEhe4IUVe6rZB_RhJO7R_T_fBBBdbsh-_tvUScs3olDEV39l27adMhEwImZ6QMZOShzJOolMypkyokAoqRuTC-09KOWOcnpMRHyDJlBqTjzk2FQa5XaILKtgMcVWCx8BhBy6DzrZNYEpoCvQBeN8aCx1mwbftygAKDB1Wu0INpq_ABRkW2KDbDV6Ssxwqj1eHPCHvT49vs3m4eH1-mT0sQhMlcRcqiAVwA8pwxIgiM5jSbVHKnEdcMciGV6VYJkxRlskkzhMTq1yksZFgZDQh93vdVb-sMTPYdA4qvXK2BrfRLVj9v9PYUhftWgueCp6kg8DtQcC1Xz36TtfWG6wqaLDtvR628yhRgvMBDfeoca33DvPjGkb11hG9dUQzoXeODPzN39uO9K8F0Q89Y4mh</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>VanNasdale, Dean A</creator><creator>Elsner, Ann E</creator><creator>Peabody, Todd D</creator><creator>Kohne, Kimberly D</creator><creator>Malinovsky, Victor E</creator><creator>Haggerty, Bryan P</creator><creator>Weber, Anke</creator><creator>Clark, Christopher A</creator><creator>Burns, Stephen A</creator><general>The Association for Research in Vision and Ophthalmology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150101</creationdate><title>Henle fiber layer phase retardation changes associated with age-related macular degeneration</title><author>VanNasdale, Dean A ; Elsner, Ann E ; Peabody, Todd D ; Kohne, Kimberly D ; Malinovsky, Victor E ; Haggerty, Bryan P ; Weber, Anke ; Clark, Christopher A ; Burns, Stephen A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-6a74a2ca6c2ee30e1ce906a7455f23261ad11654b81601d587f8c76f497c5ac53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Macula Lutea - pathology</topic><topic>Macular Degeneration - diagnosis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Retinal Cone Photoreceptor Cells - pathology</topic><topic>Retinal Ganglion Cells - pathology</topic><topic>Scanning Laser Polarimetry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VanNasdale, Dean A</creatorcontrib><creatorcontrib>Elsner, Ann E</creatorcontrib><creatorcontrib>Peabody, Todd D</creatorcontrib><creatorcontrib>Kohne, Kimberly D</creatorcontrib><creatorcontrib>Malinovsky, Victor E</creatorcontrib><creatorcontrib>Haggerty, Bryan P</creatorcontrib><creatorcontrib>Weber, Anke</creatorcontrib><creatorcontrib>Clark, Christopher A</creatorcontrib><creatorcontrib>Burns, Stephen A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Investigative ophthalmology & visual science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VanNasdale, Dean A</au><au>Elsner, Ann E</au><au>Peabody, Todd D</au><au>Kohne, Kimberly D</au><au>Malinovsky, Victor E</au><au>Haggerty, Bryan P</au><au>Weber, Anke</au><au>Clark, Christopher A</au><au>Burns, Stephen A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Henle fiber layer phase retardation changes associated with age-related macular degeneration</atitle><jtitle>Investigative ophthalmology & visual science</jtitle><addtitle>Invest Ophthalmol Vis Sci</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>56</volume><issue>1</issue><spage>284</spage><epage>290</epage><pages>284-290</pages><issn>0146-0404</issn><eissn>1552-5783</eissn><abstract>To quantify and compare phase retardation amplitude and regularity associated with the Henle fiber layer (HFL) between nonexudative AMD patients and age-matched controls using scanning laser polarimetry (SLP) imaging.
A scanning laser polarimeter was used to collect 15 × 15° macular-centered images in 25 patients with nonexudative AMD and 25 age-matched controls. Raw image data were used to compute macular phase retardation maps associated with the HFL. Consecutive, annular regions of interest from 0.5 to 3.0° eccentricity, centered on the fovea, were used to generate intensity profiles from phase retardation data and analyzed with two complementary techniques: a normalized second harmonic frequency (2f) of the fast Fourier Transform (FFT) analysis and a curve fitting analysis using a 2f sine function. Paired t-tests were used to compare the normalized 2f FFT magnitude at each eccentricity between the two groups, the eccentricity that yielded the maximum normalized 2f FFT between paired individuals across the two groups, and curve fitting RMS error at each eccentricity between the two groups.
Normalized 2f FFT components were lower in the AMD group at each eccentricity, with no difference between the two groups in the maximum normalized 2f FFT component eccentricity. The root-mean-square (RMS) error from curve fitting was significantly higher in the AMD group.
Phase retardation changes in the central macula indicate loss and/or structural alterations to central cone photoreceptors in nonexudative AMD patients. Scanning laser polarimetry imaging is a noninvasive method for quantifying cone photoreceptor changes associated with central macular disease.</abstract><cop>United States</cop><pub>The Association for Research in Vision and Ophthalmology</pub><pmid>25525166</pmid><doi>10.1167/iovs.14-14459</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Aged Aged, 80 and over Disease Progression Female Follow-Up Studies Humans Macula Lutea - pathology Macular Degeneration - diagnosis Male Middle Aged Retinal Cone Photoreceptor Cells - pathology Retinal Ganglion Cells - pathology Scanning Laser Polarimetry |
title | Henle fiber layer phase retardation changes associated with age-related macular degeneration |
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