CD73-generated adenosine is critical for immune regulation during Toxoplasma gondii infection

As an obligate intracellular pathogen, the apicomplexan parasite Toxoplasma gondii evades immune system-mediated clearance by undergoing stage differentiation to persist indefinitely in susceptible hosts. Previously, we found that mice deficient in the ectoenzyme CD73, which generates adenosine in t...

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Veröffentlicht in:	Infection and immunity 2015-02, Vol.83 (2), p.721-729
Hauptverfasser:	Mahamed, Deeqa A, Toussaint, Leon E, Bynoe, Margaret S
Format:	Artikel
Sprache:	eng
Schlagworte:	5'-Nucleotidase - genetics 5'-Nucleotidase - metabolism Adenosine - genetics Adenosine - immunology Adenosine-5'-(N-ethylcarboxamide) - pharmacology Animals Antineoplastic Agents - pharmacology CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Cells, Cultured Fungal and Parasitic Infections Inflammation - genetics Inflammation - immunology Inflammation Mediators - blood Interleukin-1beta - blood Lymphocyte Activation - immunology Mice Mice, Inbred C57BL Mice, Knockout Neutrophil Infiltration - immunology Neutrophils - immunology Nitric Oxide - biosynthesis Purinergic P1 Receptor Agonists - pharmacology Toxoplasma - immunology Toxoplasma gondii Toxoplasmosis - immunology Tumor Necrosis Factor-alpha - blood
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