Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey

Background and Purpose Endogenous cannabinoids (endocannabinoids) in the periaqueductal grey (PAG) play a vital role in mediating stress‐induced analgesia. This analgesic effect of endocannabinoids is enhanced by pharmacological inhibition of their degradative enzymes. However, the specific effects...

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Veröffentlicht in:	British journal of pharmacology 2014-12, Vol.171 (23), p.5225-5236
Hauptverfasser:	Lau, Benjamin K, Drew, Geoffrey M, Mitchell, Vanessa A, Vaughan, Christopher W
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases - antagonists & inhibitors Amidohydrolases - physiology Analgesics Animals Arachidonic Acids - physiology Benzamides - pharmacology Benzodioxoles - pharmacology Carbamates - pharmacology Endocannabinoids - physiology Enzymes Female Glycerides - physiology In Vitro Techniques Inhibitory Postsynaptic Potentials Male Monoacylglycerol Lipases - antagonists & inhibitors Monoacylglycerol Lipases - physiology Neurons - drug effects Neurons - physiology Pain - drug therapy Pain - metabolism Pain - physiopathology Periaqueductal Gray - drug effects Periaqueductal Gray - physiology Piperidines - pharmacology Polyunsaturated Alkamides Rats, Sprague-Dawley Receptor, Cannabinoid, CB1 - physiology Research Papers Rodents Synaptic Transmission - drug effects
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