Surface-templated hydrogel patterns prompt matrix-dependent migration of breast cancer cells towards chemokine-secreting cells

[Display omitted] This paper describes a novel technique for fabricating spatially defined cell-laden collagen hydrogels, using patterned, non-adhesive polyacrylamide-coated polydimethylsiloxane (PDMS) surfaces as a template. Precisely patterned embedded co-cultures of breast cancer cells and chemok...

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Veröffentlicht in:	Acta biomaterialia 2015-02, Vol.13, p.68-77
Hauptverfasser:	Kojima, Taisuke, Moraes, Christopher, Cavnar, Stephen P., Luker, Gary D., Takayama, Shuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Breast Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cell Line, Tumor Cell migration Cell Movement Chemokine CXCL12 - metabolism Collagens Electrochemical machining Extracellular Matrix - chemistry Female Gradient Humans Hydrogels Hydrogels - chemistry Micropatterning Migration Neoplasm Proteins - metabolism Receptors, CXCR4 - metabolism Silicone resins Surface modification Three dimensional
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