Presynaptic inhibition of spinal sensory feedback ensures smooth movement

The precision of skilled movement depends on sensory feedback and its refinement by local inhibitory microcircuits. One specialized set of spinal GABAergic interneurons forms axo–axonic contacts with the central terminals of sensory afferents, exerting presynaptic inhibitory control over sensory–mot...

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Veröffentlicht in:	Nature (London) 2014-05, Vol.509 (7498), p.43-48
Hauptverfasser:	Fink, Andrew J. P., Croce, Katherine R., Huang, Z. Josh, Abbott, L. F., Jessell, Thomas M., Azim, Eiman
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 14/1 14/19 42/41 42/44 631/378/1697/1691 631/378/2629/1779 631/378/2632/1664 631/378/2632/1823 64/60 9/74 Animal locomotion Animals Axons - physiology Control systems Efferent Pathways - physiology Feedback, Sensory - physiology Female Forelimb - physiology GABAergic Neurons - cytology GABAergic Neurons - metabolism Glutamate Decarboxylase - genetics Glutamate Decarboxylase - metabolism Humanities and Social Sciences Interneurons - cytology Interneurons - metabolism Male Mice Models, Neurological Motor Skills - physiology Movement - physiology multidisciplinary Neural Inhibition - physiology Neurology Neurons Neurotransmitter Agents - secretion Physiological research Presynaptic Terminals - physiology Rodents Science Spinal cord Spinal Cord - physiology Studies
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