Integrator Regulates Transcriptional Initiation and Pause Release following Activation

In unicellular organisms, initiation is the rate-limiting step in transcription; in metazoan organisms, the transition from initiation to productive elongation is also important. Here, we show that the RNA polymerase II (RNAPII)-associated multiprotein complex, Integrator, plays a critical role in b...

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Veröffentlicht in:	Molecular cell 2014-10, Vol.56 (1), p.128-139
Hauptverfasser:	Gardini, Alessandro, Baillat, David, Cesaroni, Matteo, Hu, Deqing, Marinis, Jill M., Wagner, Eric J., Lazar, Mitchell A., Shilatifard, Ali, Shiekhattar, Ramin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animalia DNA-directed RNA polymerase epidermal growth factor Epidermal Growth Factor - metabolism Epidermal Growth Factor - physiology genes HeLa Cells Humans Metazoa multiprotein complexes RNA Polymerase II - metabolism transcription (genetics) Transcription Initiation, Genetic Transcriptional Activation
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