Mathematical models of electrical activity of the pancreatic β-cell: A physiological review
Mathematical modeling of the electrical activity of the pancreatic β-cell has been extremely important for understanding the cellular mechanisms involved in glucose-stimulated insulin secretion. Several models have been proposed over the last 30 y, growing in complexity as experimental evidence of t...
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| Veröffentlicht in: | Islets 2014-01, Vol.6 (3), p.e949195-e949195 |
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| creator | Félix-Martínez, Gerardo J Godínez-Fernández, J Rafael |
| description | Mathematical modeling of the electrical activity of the pancreatic β-cell has been extremely important for understanding the cellular mechanisms involved in glucose-stimulated insulin secretion. Several models have been proposed over the last 30 y, growing in complexity as experimental evidence of the cellular mechanisms involved has become available. Almost all the models have been developed based on experimental data from rodents. However, given the many important differences between species, models of human β-cells have recently been developed. This review summarizes how modeling of β-cells has evolved, highlighting the proposed physiological mechanisms underlying β-cell electrical activity. |
| doi_str_mv | 10.4161/19382014.2014.949195 |
| format | Article |
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Several models have been proposed over the last 30 y, growing in complexity as experimental evidence of the cellular mechanisms involved has become available. Almost all the models have been developed based on experimental data from rodents. However, given the many important differences between species, models of human β-cells have recently been developed. This review summarizes how modeling of β-cells has evolved, highlighting the proposed physiological mechanisms underlying β-cell electrical activity.</description><identifier>ISSN: 1938-2014</identifier><identifier>EISSN: 1938-2022</identifier><identifier>DOI: 10.4161/19382014.2014.949195</identifier><identifier>PMID: 25322829</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>action potentials ; Animals ; bursting ; calcium ; Calcium - physiology ; Computer Simulation ; electrical activity ; Glucose - metabolism ; Humans ; Insulin - metabolism ; Insulin Secretion ; Insulin-Secreting Cells - metabolism ; Insulin-Secreting Cells - physiology ; ion channels ; mathematical model ; Models, Biological ; Potassium Channels - physiology ; Review ; β-cell</subject><ispartof>Islets, 2014-01, Vol.6 (3), p.e949195-e949195</ispartof><rights>2014 The Author(s). Published with license by Taylor & Francis Group, LLC © Gerardo J Félix-Martínez and J Rafael Godínez-Fernández 2014</rights><rights>2014 The Author(s). 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This review summarizes how modeling of β-cells has evolved, highlighting the proposed physiological mechanisms underlying β-cell electrical activity.</description><subject>action potentials</subject><subject>Animals</subject><subject>bursting</subject><subject>calcium</subject><subject>Calcium - physiology</subject><subject>Computer Simulation</subject><subject>electrical activity</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>Insulin - metabolism</subject><subject>Insulin Secretion</subject><subject>Insulin-Secreting Cells - metabolism</subject><subject>Insulin-Secreting Cells - physiology</subject><subject>ion channels</subject><subject>mathematical model</subject><subject>Models, Biological</subject><subject>Potassium Channels - physiology</subject><subject>Review</subject><subject>β-cell</subject><issn>1938-2014</issn><issn>1938-2022</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><recordid>eNp9UUtOwzAUtBCI_w0QypJNwP_ELEAV4icVsYEdkuU6DjVy4mK7Rb0WB-FMJG2pYMPm2RrPzPN7A8ARgqcUcXSGBCkxRPR0UQQVSLANsNvDOYYYb67viO6AvRjfIOQCQ7oNdjAjGJdY7IKXB5XGplHJauWyxlfGxczXmXFGp7AAlU52ZtO8hztuNlGtDqZXZF-fuTbOnWeDbDKeR-udf11ogplZ83EAtmrlojlcnfvg-eb66eouHz7e3l8NhrmmnKa8UCWkAjI8MpzwglUF57qCRHPORqwssGCwxmU3LhElw5WGBDOkFCMM8pKNyD64WPpOpqPGVNq0KSgnJ8E2KsylV1b-fWntWL76maRYYFYUncHJyiD496mJSTY29pOp1vhplN2-iaBciJ5Kl1QdfIzB1Os2CMo-GPkTjFyUZTCd7Pj3F9einyQ6wuWSYNvah0Z9-OAqmdTc-VCHbuU2SvJvi28nBZ10</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Félix-Martínez, Gerardo J</creator><creator>Godínez-Fernández, J Rafael</creator><general>Taylor & Francis</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140101</creationdate><title>Mathematical models of electrical activity of the pancreatic β-cell: A physiological review</title><author>Félix-Martínez, Gerardo J ; Godínez-Fernández, J Rafael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-7a8049052be63675d766cd03c665b5872950f2838239852dc03251aa5350685b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>action potentials</topic><topic>Animals</topic><topic>bursting</topic><topic>calcium</topic><topic>Calcium - physiology</topic><topic>Computer Simulation</topic><topic>electrical activity</topic><topic>Glucose - metabolism</topic><topic>Humans</topic><topic>Insulin - metabolism</topic><topic>Insulin Secretion</topic><topic>Insulin-Secreting Cells - metabolism</topic><topic>Insulin-Secreting Cells - physiology</topic><topic>ion channels</topic><topic>mathematical model</topic><topic>Models, Biological</topic><topic>Potassium Channels - physiology</topic><topic>Review</topic><topic>β-cell</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Félix-Martínez, Gerardo J</creatorcontrib><creatorcontrib>Godínez-Fernández, J Rafael</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Islets</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Félix-Martínez, Gerardo J</au><au>Godínez-Fernández, J Rafael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mathematical models of electrical activity of the pancreatic β-cell: A physiological review</atitle><jtitle>Islets</jtitle><addtitle>Islets</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>6</volume><issue>3</issue><spage>e949195</spage><epage>e949195</epage><pages>e949195-e949195</pages><issn>1938-2014</issn><eissn>1938-2022</eissn><abstract>Mathematical modeling of the electrical activity of the pancreatic β-cell has been extremely important for understanding the cellular mechanisms involved in glucose-stimulated insulin secretion. 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| fulltext | fulltext |
| identifier | ISSN: 1938-2014 |
| ispartof | Islets, 2014-01, Vol.6 (3), p.e949195-e949195 |
| issn | 1938-2014 1938-2022 |
| language | eng |
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| source | MEDLINE; PubMed Central; EZB Electronic Journals Library |
| subjects | action potentials Animals bursting calcium Calcium - physiology Computer Simulation electrical activity Glucose - metabolism Humans Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - physiology ion channels mathematical model Models, Biological Potassium Channels - physiology Review β-cell |
| title | Mathematical models of electrical activity of the pancreatic β-cell: A physiological review |
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