Single-Cell Transcriptome Analysis Reveals Dynamic Changes in lncRNA Expression during Reprogramming

Cellular reprogramming highlights the epigenetic plasticity of the somatic cell state. Long noncoding RNAs (lncRNAs) have emerging roles in epigenetic regulation, but their potential functions in reprogramming cell fate have been largely unexplored. We used single-cell RNA sequencing to characterize...

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Veröffentlicht in:	Cell stem cell 2015-01, Vol.16 (1), p.88-101
Hauptverfasser:	Kim, Daniel H., Marinov, Georgi K., Pepke, Shirley, Singer, Zakary S., He, Peng, Williams, Brian, Schroth, Gary P., Elowitz, Michael B., Wold, Barbara J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Lineage - genetics Cellular Reprogramming - genetics Gene Expression Regulation, Developmental Genes, Developmental Hematopoiesis - genetics Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Mice Pluripotent Stem Cells - metabolism ras Proteins - metabolism RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Signal Transduction - genetics Single-Cell Analysis - methods Transcriptome - genetics
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