High-content screening technology combined with a human granuloma model as a new approach to evaluate the activities of drugs against Mycobacterium tuberculosis

Tuberculosis remains a major health problem due to the emergence of drug-resistant strains of Mycobacterium tuberculosis. Some models have provided valuable information about drug resistance and efficacy; however, the translation of these results into effective human treatments has mostly proven uns...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2015-01, Vol.59 (1), p.693-697
Hauptverfasser:	Silva-Miranda, Mayra, Ekaza, Euloge, Breiman, Adrien, Asehnoune, Karim, Barros-Aguirre, David, Pethe, Kevin, Ewann, Fanny, Brodin, Priscille, Ballell-Pages, Lluís, Altare, Frédéric
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitubercular Agents Antitubercular Agents - pharmacology Dose-Response Relationship, Drug Granuloma Granuloma - drug therapy High-Throughput Screening Assays High-Throughput Screening Assays - methods Humans Immunology Life Sciences Microbial Sensitivity Tests Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Susceptibility Tuberculosis, Pulmonary - drug therapy
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