Perturbed thymopoiesis in vitro in the absence of suppressor of cytokine signalling 1 and 3

Cytokine signals are central to the differentiation of thymocytes and their stepwise progression through defined developmental stages. The intensity and duration of cytokine signals are regulated by the suppressor of cytokine signalling (SOCS) proteins. A clear role for SOCS1 during the later stages...

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