Pseudo-outbreak of Actinomyces graevenitzii associated with bronchoscopy
Outbreaks and pseudo-outbreaks of infection related to bronchoscopy typically involve Gram-negative bacteria, Mycobacterium species or Legionella species. We report an unusual bronchoscopy-related pseudo-outbreak due to Actinomyces graevenitzii. Extensive epidemiological and microbiological investig...
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| Veröffentlicht in: | Journal of clinical microbiology 2015-01, Vol.53 (1), p.113-117 |
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| container_title | Journal of clinical microbiology |
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| creator | Peaper, David R Havill, Nancy L Aniskiewicz, Michael Callan, Deborah Pop, Olivia Towle, Dana Boyce, John M |
| description | Outbreaks and pseudo-outbreaks of infection related to bronchoscopy typically involve Gram-negative bacteria, Mycobacterium species or Legionella species. We report an unusual bronchoscopy-related pseudo-outbreak due to Actinomyces graevenitzii. Extensive epidemiological and microbiological investigation failed to identify a common source. Strain typing revealed that the cluster was comprised of heterogeneous strains of A. graevenitzii. A change in laboratory procedures for Actinomyces cultures was coincident with the emergence of the pseudo-outbreak, and we determined that A. graevenitzii isolates more readily adopted a white, dry, molar tooth appearance on anaerobic colistin nalidixic acid (CNA) agar which likely facilitated its detection and identification in bronchoscopic specimens. This unusual pseudo-outbreak was related to frequent requests of bronchoscopists for Actinomyces cultures combined with a change in microbiology laboratory practices. |
| doi_str_mv | 10.1128/JCM.02302-14 |
| format | Article |
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C.</contributor><creatorcontrib>Peaper, David R ; Havill, Nancy L ; Aniskiewicz, Michael ; Callan, Deborah ; Pop, Olivia ; Towle, Dana ; Boyce, John M ; Carroll, K. C.</creatorcontrib><description>Outbreaks and pseudo-outbreaks of infection related to bronchoscopy typically involve Gram-negative bacteria, Mycobacterium species or Legionella species. We report an unusual bronchoscopy-related pseudo-outbreak due to Actinomyces graevenitzii. Extensive epidemiological and microbiological investigation failed to identify a common source. Strain typing revealed that the cluster was comprised of heterogeneous strains of A. graevenitzii. A change in laboratory procedures for Actinomyces cultures was coincident with the emergence of the pseudo-outbreak, and we determined that A. graevenitzii isolates more readily adopted a white, dry, molar tooth appearance on anaerobic colistin nalidixic acid (CNA) agar which likely facilitated its detection and identification in bronchoscopic specimens. This unusual pseudo-outbreak was related to frequent requests of bronchoscopists for Actinomyces cultures combined with a change in microbiology laboratory practices.</description><identifier>ISSN: 0095-1137</identifier><identifier>EISSN: 1098-660X</identifier><identifier>DOI: 10.1128/JCM.02302-14</identifier><identifier>PMID: 25355767</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>Actinomyces - classification ; Actinomyces - genetics ; Actinomycosis - epidemiology ; Actinomycosis - microbiology ; Bacterial Load ; Bronchoscopy - adverse effects ; Case-Control Studies ; Cross Infection ; Disease Outbreaks ; Epidemiology ; Equipment Contamination ; Humans ; Polymerase Chain Reaction ; Tertiary Care Centers</subject><ispartof>Journal of clinical microbiology, 2015-01, Vol.53 (1), p.113-117</ispartof><rights>Copyright © 2015, American Society for Microbiology. All Rights Reserved.</rights><rights>Copyright © 2015, American Society for Microbiology. All Rights Reserved. 2015 American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-470621e8cd672f9a579431f04ba3ea5d31e5e7c28984e4cf891be7748b6c7c683</citedby><cites>FETCH-LOGICAL-c384t-470621e8cd672f9a579431f04ba3ea5d31e5e7c28984e4cf891be7748b6c7c683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4290908/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4290908/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,3188,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25355767$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Carroll, K. C.</contributor><creatorcontrib>Peaper, David R</creatorcontrib><creatorcontrib>Havill, Nancy L</creatorcontrib><creatorcontrib>Aniskiewicz, Michael</creatorcontrib><creatorcontrib>Callan, Deborah</creatorcontrib><creatorcontrib>Pop, Olivia</creatorcontrib><creatorcontrib>Towle, Dana</creatorcontrib><creatorcontrib>Boyce, John M</creatorcontrib><title>Pseudo-outbreak of Actinomyces graevenitzii associated with bronchoscopy</title><title>Journal of clinical microbiology</title><addtitle>J Clin Microbiol</addtitle><description>Outbreaks and pseudo-outbreaks of infection related to bronchoscopy typically involve Gram-negative bacteria, Mycobacterium species or Legionella species. We report an unusual bronchoscopy-related pseudo-outbreak due to Actinomyces graevenitzii. Extensive epidemiological and microbiological investigation failed to identify a common source. Strain typing revealed that the cluster was comprised of heterogeneous strains of A. graevenitzii. A change in laboratory procedures for Actinomyces cultures was coincident with the emergence of the pseudo-outbreak, and we determined that A. graevenitzii isolates more readily adopted a white, dry, molar tooth appearance on anaerobic colistin nalidixic acid (CNA) agar which likely facilitated its detection and identification in bronchoscopic specimens. This unusual pseudo-outbreak was related to frequent requests of bronchoscopists for Actinomyces cultures combined with a change in microbiology laboratory practices.</description><subject>Actinomyces - classification</subject><subject>Actinomyces - genetics</subject><subject>Actinomycosis - epidemiology</subject><subject>Actinomycosis - microbiology</subject><subject>Bacterial Load</subject><subject>Bronchoscopy - adverse effects</subject><subject>Case-Control Studies</subject><subject>Cross Infection</subject><subject>Disease Outbreaks</subject><subject>Epidemiology</subject><subject>Equipment Contamination</subject><subject>Humans</subject><subject>Polymerase Chain Reaction</subject><subject>Tertiary Care Centers</subject><issn>0095-1137</issn><issn>1098-660X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkLFOwzAQQC0EglLYmFFGBlLs2I7tBQlVQEFFMIDEZjnOpTU0cbGTovL1tBQQTDfc07vTQ-iI4AEhmTy7Hd4NcEZxlhK2hXoEK5nmOX7eRj2MFU8JoWIP7cf4gjFhjPNdtJdxyrnIRQ-NHiJ0pU991xYBzGviq-TCtq7x9dJCTCbBwAIa1344l5gYvXWmhTJ5d-00KYJv7NRH6-fLA7RTmVmEw-_ZR09Xl4_DUTq-v74ZXoxTSyVrUyZwnhGQtsxFVinDhWKUVJgVhoLhJSXAQdhMKsmA2UoqUoAQTBa5FTaXtI_ON955V9RQWmjaYGZ6HlxtwlJ74_T_TeOmeuIXmmUKK7wWnHwLgn_rILa6dtHCbGYa8F3UJKeKSSElW6GnG9QGH2OA6vcMwXodX6_i66_4mqzx47-v_cI_teknQHSBWA</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Peaper, David R</creator><creator>Havill, Nancy L</creator><creator>Aniskiewicz, Michael</creator><creator>Callan, Deborah</creator><creator>Pop, Olivia</creator><creator>Towle, Dana</creator><creator>Boyce, John M</creator><general>American Society for Microbiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150101</creationdate><title>Pseudo-outbreak of Actinomyces graevenitzii associated with bronchoscopy</title><author>Peaper, David R ; Havill, Nancy L ; Aniskiewicz, Michael ; Callan, Deborah ; Pop, Olivia ; Towle, Dana ; Boyce, John M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-470621e8cd672f9a579431f04ba3ea5d31e5e7c28984e4cf891be7748b6c7c683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Actinomyces - classification</topic><topic>Actinomyces - genetics</topic><topic>Actinomycosis - epidemiology</topic><topic>Actinomycosis - microbiology</topic><topic>Bacterial Load</topic><topic>Bronchoscopy - adverse effects</topic><topic>Case-Control Studies</topic><topic>Cross Infection</topic><topic>Disease Outbreaks</topic><topic>Epidemiology</topic><topic>Equipment Contamination</topic><topic>Humans</topic><topic>Polymerase Chain Reaction</topic><topic>Tertiary Care Centers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peaper, David R</creatorcontrib><creatorcontrib>Havill, Nancy L</creatorcontrib><creatorcontrib>Aniskiewicz, Michael</creatorcontrib><creatorcontrib>Callan, Deborah</creatorcontrib><creatorcontrib>Pop, Olivia</creatorcontrib><creatorcontrib>Towle, Dana</creatorcontrib><creatorcontrib>Boyce, John M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peaper, David R</au><au>Havill, Nancy L</au><au>Aniskiewicz, Michael</au><au>Callan, Deborah</au><au>Pop, Olivia</au><au>Towle, Dana</au><au>Boyce, John M</au><au>Carroll, K. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pseudo-outbreak of Actinomyces graevenitzii associated with bronchoscopy</atitle><jtitle>Journal of clinical microbiology</jtitle><addtitle>J Clin Microbiol</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>53</volume><issue>1</issue><spage>113</spage><epage>117</epage><pages>113-117</pages><issn>0095-1137</issn><eissn>1098-660X</eissn><abstract>Outbreaks and pseudo-outbreaks of infection related to bronchoscopy typically involve Gram-negative bacteria, Mycobacterium species or Legionella species. We report an unusual bronchoscopy-related pseudo-outbreak due to Actinomyces graevenitzii. Extensive epidemiological and microbiological investigation failed to identify a common source. Strain typing revealed that the cluster was comprised of heterogeneous strains of A. graevenitzii. 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| source | MEDLINE; American Society for Microbiology Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Actinomyces - classification Actinomyces - genetics Actinomycosis - epidemiology Actinomycosis - microbiology Bacterial Load Bronchoscopy - adverse effects Case-Control Studies Cross Infection Disease Outbreaks Epidemiology Equipment Contamination Humans Polymerase Chain Reaction Tertiary Care Centers |
| title | Pseudo-outbreak of Actinomyces graevenitzii associated with bronchoscopy |
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