Acute and chronic B cell depletion disrupts CD4+ and CD8+ T cell homeostasis and expansion during acute viral infection in mice

B cells provide humoral protection against pathogens and promote cellular immunity through diverse nonclassical effector functions. To assess B cell function in promoting T cell homeostasis, mature B cells were either acutely or chronically depleted in mice using CD20 mAb. Acute B cell depletion in...

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Veröffentlicht in:	The Journal of immunology (1950) 2014-07, Vol.193 (2), p.746-756
Hauptverfasser:	Lykken, Jacquelyn M, DiLillo, David J, Weimer, Eric T, Roser-Page, Susanne, Heise, Mark T, Grayson, Jason M, Weitzmann, M Neale, Tedder, Thomas F
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals B-Lymphocytes - immunology B-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Proliferation Flow Cytometry Forkhead Transcription Factors - immunology Forkhead Transcription Factors - metabolism Homeostasis - immunology Host-Pathogen Interactions - immunology Interferon-gamma - immunology Interferon-gamma - metabolism Interleukin-2 Receptor alpha Subunit - immunology Interleukin-2 Receptor alpha Subunit - metabolism Lymph Nodes - immunology Lymph Nodes - metabolism Lymphocyte Count Lymphocyte Depletion Lymphocytic Choriomeningitis - immunology Lymphocytic Choriomeningitis - virology Lymphocytic choriomeningitis virus Lymphocytic choriomeningitis virus - immunology Lymphocytic choriomeningitis virus - physiology Mice Mice, Inbred C57BL Spleen - immunology Spleen - metabolism T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism
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