Blonanserin ameliorates phencyclidine-induced visual-recognition memory deficits: the complex mechanism of blonanserin action involving D₃-5-HT₂A and D₁-NMDA receptors in the mPFC

Blonanserin differs from currently used serotonin 5-HT₂A/dopamine-D₂ receptor antagonists in that it exhibits higher affinity for dopamine-D₂/₃ receptors than for serotonin 5-HT₂A receptors. We investigated the involvement of dopamine-D₃ receptors in the effects of blonanserin on cognitive impairmen...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2015-02, Vol.40 (3), p.601-613
Hauptverfasser:	Hida, Hirotake, Mouri, Akihiro, Mori, Kentaro, Matsumoto, Yurie, Seki, Takeshi, Taniguchi, Masayuki, Yamada, Kiyofumi, Iwamoto, Kunihiro, Ozaki, Norio, Nabeshima, Toshitaka, Noda, Yukihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamines - pharmacology Animal cognition Animals Benzazepines - pharmacology Benzodiazepines - antagonists & inhibitors Benzodiazepines - pharmacology Cognitive ability Dopamine Dopamine - metabolism Dopamine Agonists - pharmacology Experiments Isoquinolines - pharmacology Kinases Laboratory animals Male Memory Mice Original Pharmacy Phencyclidine - antagonists & inhibitors Phencyclidine - pharmacology Phosphorylation - drug effects Piperazines - pharmacology Piperidines - pharmacology Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Protein Kinase Inhibitors - pharmacology Receptors, Dopamine D1 - metabolism Receptors, Dopamine D3 - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Recognition (Psychology) - drug effects Schizophrenia Serotonin Serotonin Receptor Agonists - pharmacology Sulfonamides - pharmacology Tetrahydronaphthalenes - pharmacology
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