The conserved hypothetical protein Rv0574c is required for cell wall integrity, stress tolerance, and virulence of Mycobacterium tuberculosis

The virulence of Mycobacterium tuberculosis is intimately related to its distinctive cell wall. The biological significance of poly-α-L-glutamine (PLG), a component in the cell wall of virulent mycobacteria, has not been explored adequately. The focus of this study is to investigate the role of a lo...

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Veröffentlicht in:	Infection and immunity 2015-01, Vol.83 (1), p.120-129
Hauptverfasser:	Garg, Rajni, Tripathi, Deeksha, Kant, Sashi, Chandra, Harish, Bhatnagar, Rakesh, Banerjee, Nirupama
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Infections Biofilms - growth & development Cell Wall - chemistry Cell Wall - physiology Disease Models, Animal Female Gene Deletion Gene Expression Profiling Humans Lung - microbiology Lung - pathology Mice, Inbred BALB C Monocytes - microbiology Mycobacterium Mycobacterium tuberculosis Mycobacterium tuberculosis - cytology Mycobacterium tuberculosis - enzymology Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - pathogenicity Peptide Synthases - genetics Peptide Synthases - metabolism Peptides - metabolism Spleen - microbiology Stress, Physiological Tuberculosis - microbiology Tuberculosis - pathology Virulence
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