Plasmid-mediated quinolone resistance

Three mechanisms for plasmid-mediated quinolone resistance (PMQR) have been discovered since 1998. Plasmid genes qnrA, qnrB, qnrC, qnrD, qnrS, and qnrVC code for proteins of the pentapeptide repeat family that protects DNA gyrase and topoisomerase IV from quinolone inhibition. The qnr genes appear t...

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Veröffentlicht in:	Microbiology spectrum 2014-10, Vol.2 (5)
Hauptverfasser:	Jacoby, George A, Strahilevitz, Jacob, Hooper, David C
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Anti-Bacterial Agents Anti-Bacterial Agents - pharmacology Bacteria Bacteria - drug effects Bacteria - genetics Bacterial Proteins - genetics Bacterial Proteins - metabolism Biological Transport DNA Gyrase - metabolism DNA Topoisomerase IV - metabolism Drug Resistance, Bacterial Inactivation, Metabolic Plasmids Quinolones Quinolones - metabolism Quinolones - pharmacology Review Article
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