Hydrogen sulphide decreases IL‐1β‐induced activation of fibroblast‐like synoviocytes from patients with osteoarthritis

Balneotherapy employing sulphurous thermal water is still applied to patients suffering from diseases of musculoskeletal system like osteoarthritis (OA) but evidence for its clinical effectiveness is scarce. Since the gasotransmitter hydrogen sulphide (H2S) seems to affect cells involved in degenera...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2015-01, Vol.19 (1), p.187-197
Hauptverfasser:	Sieghart, Daniela, Liszt, Melissa, Wanivenhaus, Axel, Bröll, Hans, Kiener, Hans, Klösch, Burkhard, Steiner, Günter
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Activation AKT protein AKT1 protein Arthritis Cell culture Cell Survival - drug effects Cells, Cultured Cellular structure Chemokine CCL5 - secretion Disease Drug development Enzyme Activation - drug effects Enzyme-linked immunosorbent assay Enzymes Extracellular matrix Extracellular Space - drug effects Extracellular Space - metabolism Fibroblasts Fibroblasts - drug effects Fibroblasts - enzymology Fibroblasts - pathology fibroblast‐like synoviocytes Humans Hydrogen Hydrogen ion concentration Hydrogen sulfide Hydrogen Sulfide - pharmacology hydrogen sulphide Hyperplasia Inflammation Interleukin-1beta - pharmacology Interleukin-6 - biosynthesis Interleukin-8 - secretion Investigations Joint diseases MAP kinase Matrix Metalloproteinase 14 - metabolism Matrix Metalloproteinase 2 - metabolism Metallography Mitogen-Activated Protein Kinases - metabolism Musculoskeletal system Original Osteoarthritis Osteoarthritis - enzymology Osteoarthritis - pathology Patients Phosphorylation Phosphorylation - drug effects Proto-Oncogene Proteins c-akt - metabolism RANTES Secretion Signal transduction Stimulation Sulfides - pharmacology Sulfur Survival factor Synovial Membrane - pathology Synoviocytes Thermal water Western blotting
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