Sirt3 is essential for apelin‐induced angiogenesis in post‐myocardial infarction of diabetes

Heart failure following myocardial infarction (MI) is the leading cause of death in diabetic patients. Angiogenesis contributes to cardiac repair and functional recovery in post‐MI. Our previous study shows that apelin (APLN) increases Sirtuin 3 (Sirt3) expression and ameliorates diabetic cardiomyop...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2015-01, Vol.19 (1), p.53-61
Hauptverfasser:	Hou, Xuwei, Zeng, Heng, He, Xiaochen, Chen, Jian‐Xiong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - metabolism Adenoviruses Adipokines Angiogenesis Angiogenesis Inducing Agents - metabolism Animals Apelin Apoptosis Bone marrow Cardiac function Cardiomyocytes Cardiomyopathy Cardiovascular disease Cell Proliferation Congestive heart failure Coronary vessels Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Experimental - physiopathology Endothelial Cells - metabolism Gene therapy Genetic Therapy Growth factors Heart attacks Heart failure Heart Function Tests Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Intercellular Signaling Peptides and Proteins - therapeutic use Laboratory animals Mice Mice, Knockout Myocardial infarction Myocardial Infarction - diagnostic imaging Myocardial Infarction - etiology Myocardial Infarction - physiopathology Myocardial Infarction - therapy Myocardium - pathology Neovascularization, Physiologic Original Progenitor cells Recovery of function sirtuin 3 Sirtuin 3 - deficiency Sirtuin 3 - metabolism Software Stem cells Streptozocin Studies Ultrasonography Vascular endothelial growth factor
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