Prospective evaluation of insulin resistance among endometrial cancer patients
Objective Obesity and estrogen are strong risk factors for endometrial cancer (EC). Whereas diabetes also increases the risk, little is known about related insulin resistance (IR). The purpose of this study was to determine the prevalence of IR in newly diagnosed EC patients. Study Design EC patient...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2011-04, Vol.204 (4), p.355.e1-355.e7 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Burzawa, Jennifer K., MD Schmeler, Kathleen M., MD Soliman, Pamela T., MD Meyer, Larissa A., MD Bevers, Michael W., MD Pustilnik, Terri L., MD Anderson, Matthew L., MD, PhD Ramondetta, Lois M., MD Tortolero-Luna, Guillermo, MD, PhD Urbauer, Diana L., MS Chang, Shine, PhD Gershenson, David M., MD Brown, Jubilee, MD Lu, Karen H., MD |
| description | Objective Obesity and estrogen are strong risk factors for endometrial cancer (EC). Whereas diabetes also increases the risk, little is known about related insulin resistance (IR). The purpose of this study was to determine the prevalence of IR in newly diagnosed EC patients. Study Design EC patients from a large, metropolitan county were prospectively enrolled from 2005 to 2008. Fasting serum was analyzed for glucose and insulin. IR was defined as a history of diabetes or a quantitative insulin sensitivity check index (QUICKI) (1/[log fasting insulin + log fasting glucose]) value of less than 0.357. Results Among 99 patients, diabetes was present in 30, and an abnormal QUICKI was found in 36 additional patients. Increased risk of IR was significantly associated with higher body mass index ( P < .001), lower socioeconomic status ( P = .007), and nulliparity ( P = .029). Conclusion IR was highly prevalent in endometrial cancer patients, including nonobese women. Better characterization of metabolic risks in addition to obesity may provide avenues for targeted cancer prevention in the future. |
| doi_str_mv | 10.1016/j.ajog.2010.11.033 |
| format | Article |
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Whereas diabetes also increases the risk, little is known about related insulin resistance (IR). The purpose of this study was to determine the prevalence of IR in newly diagnosed EC patients. Study Design EC patients from a large, metropolitan county were prospectively enrolled from 2005 to 2008. Fasting serum was analyzed for glucose and insulin. IR was defined as a history of diabetes or a quantitative insulin sensitivity check index (QUICKI) (1/[log fasting insulin + log fasting glucose]) value of less than 0.357. Results Among 99 patients, diabetes was present in 30, and an abnormal QUICKI was found in 36 additional patients. Increased risk of IR was significantly associated with higher body mass index ( P < .001), lower socioeconomic status ( P = .007), and nulliparity ( P = .029). Conclusion IR was highly prevalent in endometrial cancer patients, including nonobese women. Better characterization of metabolic risks in addition to obesity may provide avenues for targeted cancer prevention in the future.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/j.ajog.2010.11.033</identifier><identifier>PMID: 21324431</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Body Mass Index ; Continental Population Groups ; diabetes ; Diabetes Mellitus - epidemiology ; endometrial cancer ; Endometrial Neoplasms - epidemiology ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; Insulin Resistance ; Medical sciences ; Middle Aged ; obesity ; Obesity - epidemiology ; Obstetrics and Gynecology ; Parity ; Pregnancy ; Prospective Studies ; Regression Analysis ; Social Class ; Tumors</subject><ispartof>American journal of obstetrics and gynecology, 2011-04, Vol.204 (4), p.355.e1-355.e7</ispartof><rights>Mosby, Inc.</rights><rights>2011 Mosby, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Mosby, Inc. All rights reserved.</rights><rights>2010 Elsevier Inc. All rights reserved. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c605t-34bb4a204c4b30c811fd92ea925c1b165db67525b78c579c534efe3ae8557a0d3</citedby><cites>FETCH-LOGICAL-c605t-34bb4a204c4b30c811fd92ea925c1b165db67525b78c579c534efe3ae8557a0d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ajog.2010.11.033$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,782,786,887,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24065457$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21324431$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Burzawa, Jennifer K., MD</creatorcontrib><creatorcontrib>Schmeler, Kathleen M., MD</creatorcontrib><creatorcontrib>Soliman, Pamela T., MD</creatorcontrib><creatorcontrib>Meyer, Larissa A., MD</creatorcontrib><creatorcontrib>Bevers, Michael W., MD</creatorcontrib><creatorcontrib>Pustilnik, Terri L., MD</creatorcontrib><creatorcontrib>Anderson, Matthew L., MD, PhD</creatorcontrib><creatorcontrib>Ramondetta, Lois M., MD</creatorcontrib><creatorcontrib>Tortolero-Luna, Guillermo, MD, PhD</creatorcontrib><creatorcontrib>Urbauer, Diana L., MS</creatorcontrib><creatorcontrib>Chang, Shine, PhD</creatorcontrib><creatorcontrib>Gershenson, David M., MD</creatorcontrib><creatorcontrib>Brown, Jubilee, MD</creatorcontrib><creatorcontrib>Lu, Karen H., MD</creatorcontrib><title>Prospective evaluation of insulin resistance among endometrial cancer patients</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Objective Obesity and estrogen are strong risk factors for endometrial cancer (EC). Whereas diabetes also increases the risk, little is known about related insulin resistance (IR). The purpose of this study was to determine the prevalence of IR in newly diagnosed EC patients. Study Design EC patients from a large, metropolitan county were prospectively enrolled from 2005 to 2008. Fasting serum was analyzed for glucose and insulin. IR was defined as a history of diabetes or a quantitative insulin sensitivity check index (QUICKI) (1/[log fasting insulin + log fasting glucose]) value of less than 0.357. Results Among 99 patients, diabetes was present in 30, and an abnormal QUICKI was found in 36 additional patients. Increased risk of IR was significantly associated with higher body mass index ( P < .001), lower socioeconomic status ( P = .007), and nulliparity ( P = .029). Conclusion IR was highly prevalent in endometrial cancer patients, including nonobese women. Better characterization of metabolic risks in addition to obesity may provide avenues for targeted cancer prevention in the future.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Continental Population Groups</subject><subject>diabetes</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>endometrial cancer</subject><subject>Endometrial Neoplasms - epidemiology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Insulin Resistance</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>obesity</subject><subject>Obesity - epidemiology</subject><subject>Obstetrics and Gynecology</subject><subject>Parity</subject><subject>Pregnancy</subject><subject>Prospective Studies</subject><subject>Regression Analysis</subject><subject>Social Class</subject><subject>Tumors</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uk2L1EAQbURxZ1f_gAfJRTxl7O8kIAvLoquwqKCei06nMnZMusfuZGD_vR1mXD8Onoqufq9e8V4R8ozRLaNMvxq2Zgi7Ladrg22pEA_IhtGmKnWt64dkQynlZSOq-oycpzSsT97wx-SMM8GlFGxDPnyKIe3Rzu6ABR7MuJjZBV-EvnA-LaPzRcTk0my8xcJMwe8K9F2YcI7OjIVd-7HYZxb6OT0hj3ozJnx6qhfk69s3X67flbcfb95fX92WVlM1l0K2rTScSitbQW3NWN81HE3DlWUt06prdaW4aqvaqqqxSkjsURislaoM7cQFuTzO3S_thJ3N2tGMsI9uMvEOgnHw949332AXDiB5rUVV5QEvTwNi-LFgmmFyyeI4Go9hSVBryhquG5qR_Ii02akUsb9XYRTWHGCANQdYcwDGIOeQSc__3O-e8sv4DHhxAphkzdjH7KNLv3GSaiXVuufrIw6zmweHEZLNTlvsXMypQRfc__e4_Iduc6QuK37HO0xDWKLPOQGDxIHC5_VE1oNhuQrGpfgJyvq9Iw</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Burzawa, Jennifer K., MD</creator><creator>Schmeler, Kathleen M., MD</creator><creator>Soliman, Pamela T., MD</creator><creator>Meyer, Larissa A., MD</creator><creator>Bevers, Michael W., MD</creator><creator>Pustilnik, Terri L., MD</creator><creator>Anderson, Matthew L., MD, PhD</creator><creator>Ramondetta, Lois M., MD</creator><creator>Tortolero-Luna, Guillermo, MD, PhD</creator><creator>Urbauer, Diana L., MS</creator><creator>Chang, Shine, PhD</creator><creator>Gershenson, David M., MD</creator><creator>Brown, Jubilee, MD</creator><creator>Lu, Karen H., MD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110401</creationdate><title>Prospective evaluation of insulin resistance among endometrial cancer patients</title><author>Burzawa, Jennifer K., MD ; Schmeler, Kathleen M., MD ; Soliman, Pamela T., MD ; Meyer, Larissa A., MD ; Bevers, Michael W., MD ; Pustilnik, Terri L., MD ; Anderson, Matthew L., MD, PhD ; Ramondetta, Lois M., MD ; Tortolero-Luna, Guillermo, MD, PhD ; Urbauer, Diana L., MS ; Chang, Shine, PhD ; Gershenson, David M., MD ; Brown, Jubilee, MD ; Lu, Karen H., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c605t-34bb4a204c4b30c811fd92ea925c1b165db67525b78c579c534efe3ae8557a0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Continental Population Groups</topic><topic>diabetes</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>endometrial cancer</topic><topic>Endometrial Neoplasms - epidemiology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. 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Whereas diabetes also increases the risk, little is known about related insulin resistance (IR). The purpose of this study was to determine the prevalence of IR in newly diagnosed EC patients. Study Design EC patients from a large, metropolitan county were prospectively enrolled from 2005 to 2008. Fasting serum was analyzed for glucose and insulin. IR was defined as a history of diabetes or a quantitative insulin sensitivity check index (QUICKI) (1/[log fasting insulin + log fasting glucose]) value of less than 0.357. Results Among 99 patients, diabetes was present in 30, and an abnormal QUICKI was found in 36 additional patients. Increased risk of IR was significantly associated with higher body mass index ( P < .001), lower socioeconomic status ( P = .007), and nulliparity ( P = .029). Conclusion IR was highly prevalent in endometrial cancer patients, including nonobese women. Better characterization of metabolic risks in addition to obesity may provide avenues for targeted cancer prevention in the future.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>21324431</pmid><doi>10.1016/j.ajog.2010.11.033</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Biological and medical sciences Body Mass Index Continental Population Groups diabetes Diabetes Mellitus - epidemiology endometrial cancer Endometrial Neoplasms - epidemiology Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Insulin Resistance Medical sciences Middle Aged obesity Obesity - epidemiology Obstetrics and Gynecology Parity Pregnancy Prospective Studies Regression Analysis Social Class Tumors |
| title | Prospective evaluation of insulin resistance among endometrial cancer patients |
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