Prenatal exposure to phthalate esters and behavioral syndromes in children at 8 years of age: Taiwan Maternal and Infant Cohort Study
Few studies have shown an association between prenatal phthalate exposure and adverse effects on neurodevelopment and behavior in young children. We aimed to assess the relationship between prenatal exposure to phthalate esters and behavior syndromes in children at 8 years of age. A total of 122 mot...
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| Veröffentlicht in: | Environmental health perspectives 2015-01, Vol.123 (1), p.95-100 |
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| creator | Lien, Yin-Ju Ku, Hsiu-Ying Su, Pen-Hua Chen, Suh-Jen Chen, Hsiao-Yen Liao, Pao-Chi Chen, Wei-J Wang, Shu-Li |
| description | Few studies have shown an association between prenatal phthalate exposure and adverse effects on neurodevelopment and behavior in young children.
We aimed to assess the relationship between prenatal exposure to phthalate esters and behavior syndromes in children at 8 years of age.
A total of 122 mother-child pairs from the general population in central Taiwan were studied from 2000 to 2009. Mono-methyl phthalate (MMP), mono-ethyl phthalate (MEP), mono-butyl phthalate (MBP), mono-benzyl phthalate (MBzP), and three di-(2-ethylhexyl) phthalate (DEHP) metabolites-mono-2-ethylhexyl, mono-2-ethyl-5-hydroxyhexyl, and mono-2-ethyl-5-oxohexyl phthalates (MEHP, MEHHP, and MEOHP)--were measured in maternal urine collected during the third trimester of pregnancy using liquid chromatography-electrospray ionization-tandem mass spectrometry. Behavioral syndromes of children at 8 years of age were evaluated using the Child Behavior Checklist (CBCL). Associations between log10-transformed creatinine-corrected phthalate concentrations and standardized scores of the CBCL were estimated using linear regression models or multinomial logistic regressions with adjustments for potential confounders.
Externalizing problem scores were significantly higher in association with a 1-unit increase in log10-transformed creatinine-corrected concentrations of maternal MBP (β = 4.29; 95% CI: 0.59, 7.99), MEOHP (β = 3.74; 95% CI: 1.33, 6.15), and MEHP (β = 4.28 ; 95% CI: 0.03, 8.26) after adjusting for the child's sex, intelligence, and family income. Meanwhile, MBP and MEOHP were significantly associated with Delinquent Behavior and Aggressive Behavior scores. The same pattern was found for borderline and/or clinical ranges.
Our findings suggest positive associations between maternal DEHP and dibutyl phthalate (DBP) exposure and externalizing domain behavior problems in 8-year-old children. |
| doi_str_mv | 10.1289/ehp.1307154 |
| format | Article |
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We aimed to assess the relationship between prenatal exposure to phthalate esters and behavior syndromes in children at 8 years of age.
A total of 122 mother-child pairs from the general population in central Taiwan were studied from 2000 to 2009. Mono-methyl phthalate (MMP), mono-ethyl phthalate (MEP), mono-butyl phthalate (MBP), mono-benzyl phthalate (MBzP), and three di-(2-ethylhexyl) phthalate (DEHP) metabolites-mono-2-ethylhexyl, mono-2-ethyl-5-hydroxyhexyl, and mono-2-ethyl-5-oxohexyl phthalates (MEHP, MEHHP, and MEOHP)--were measured in maternal urine collected during the third trimester of pregnancy using liquid chromatography-electrospray ionization-tandem mass spectrometry. Behavioral syndromes of children at 8 years of age were evaluated using the Child Behavior Checklist (CBCL). Associations between log10-transformed creatinine-corrected phthalate concentrations and standardized scores of the CBCL were estimated using linear regression models or multinomial logistic regressions with adjustments for potential confounders.
Externalizing problem scores were significantly higher in association with a 1-unit increase in log10-transformed creatinine-corrected concentrations of maternal MBP (β = 4.29; 95% CI: 0.59, 7.99), MEOHP (β = 3.74; 95% CI: 1.33, 6.15), and MEHP (β = 4.28 ; 95% CI: 0.03, 8.26) after adjusting for the child's sex, intelligence, and family income. Meanwhile, MBP and MEOHP were significantly associated with Delinquent Behavior and Aggressive Behavior scores. The same pattern was found for borderline and/or clinical ranges.
Our findings suggest positive associations between maternal DEHP and dibutyl phthalate (DBP) exposure and externalizing domain behavior problems in 8-year-old children.</description><identifier>ISSN: 0091-6765</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/ehp.1307154</identifier><identifier>PMID: 25280125</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences</publisher><subject>Adult ; Age ; Aggressiveness ; Behavior ; Checklist ; Child ; Child Behavior Disorders - chemically induced ; Child Behavior Disorders - epidemiology ; Children ; Children & youth ; Children's Health ; Cohort analysis ; Cohort Studies ; Demographics ; Environmental aspects ; Esters ; Exposure ; Families & family life ; Female ; Health ; Health aspects ; Health risk assessment ; Humans ; Infants ; Ionization ; Linear Models ; Liquid chromatography ; Logistic Models ; Male ; Mass spectrometry ; Medical research ; Metabolites ; Mother and child ; Personal grooming ; Phthalates ; Phthalic Acids - toxicity ; Phthalic Acids - urine ; Pregnancy ; Pregnancy Trimester, Third - urine ; Prenatal exposure ; Prenatal Exposure Delayed Effects ; Prenatal influences ; Psychological aspects ; Regression ; Studies ; Taiwan - epidemiology ; Urine ; Womens health</subject><ispartof>Environmental health perspectives, 2015-01, Vol.123 (1), p.95-100</ispartof><rights>COPYRIGHT 2015 National Institute of Environmental Health Sciences</rights><rights>Copyright National Institute of Environmental Health Sciences Jan 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c745t-39dad977c9675afa7d3ca4a094e933882cad5e069cda5ce4af0ddd8315b216cf3</citedby><cites>FETCH-LOGICAL-c745t-39dad977c9675afa7d3ca4a094e933882cad5e069cda5ce4af0ddd8315b216cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286269/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286269/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25280125$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lien, Yin-Ju</creatorcontrib><creatorcontrib>Ku, Hsiu-Ying</creatorcontrib><creatorcontrib>Su, Pen-Hua</creatorcontrib><creatorcontrib>Chen, Suh-Jen</creatorcontrib><creatorcontrib>Chen, Hsiao-Yen</creatorcontrib><creatorcontrib>Liao, Pao-Chi</creatorcontrib><creatorcontrib>Chen, Wei-J</creatorcontrib><creatorcontrib>Wang, Shu-Li</creatorcontrib><title>Prenatal exposure to phthalate esters and behavioral syndromes in children at 8 years of age: Taiwan Maternal and Infant Cohort Study</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description>Few studies have shown an association between prenatal phthalate exposure and adverse effects on neurodevelopment and behavior in young children.
We aimed to assess the relationship between prenatal exposure to phthalate esters and behavior syndromes in children at 8 years of age.
A total of 122 mother-child pairs from the general population in central Taiwan were studied from 2000 to 2009. Mono-methyl phthalate (MMP), mono-ethyl phthalate (MEP), mono-butyl phthalate (MBP), mono-benzyl phthalate (MBzP), and three di-(2-ethylhexyl) phthalate (DEHP) metabolites-mono-2-ethylhexyl, mono-2-ethyl-5-hydroxyhexyl, and mono-2-ethyl-5-oxohexyl phthalates (MEHP, MEHHP, and MEOHP)--were measured in maternal urine collected during the third trimester of pregnancy using liquid chromatography-electrospray ionization-tandem mass spectrometry. Behavioral syndromes of children at 8 years of age were evaluated using the Child Behavior Checklist (CBCL). Associations between log10-transformed creatinine-corrected phthalate concentrations and standardized scores of the CBCL were estimated using linear regression models or multinomial logistic regressions with adjustments for potential confounders.
Externalizing problem scores were significantly higher in association with a 1-unit increase in log10-transformed creatinine-corrected concentrations of maternal MBP (β = 4.29; 95% CI: 0.59, 7.99), MEOHP (β = 3.74; 95% CI: 1.33, 6.15), and MEHP (β = 4.28 ; 95% CI: 0.03, 8.26) after adjusting for the child's sex, intelligence, and family income. Meanwhile, MBP and MEOHP were significantly associated with Delinquent Behavior and Aggressive Behavior scores. The same pattern was found for borderline and/or clinical ranges.
Our findings suggest positive associations between maternal DEHP and dibutyl phthalate (DBP) exposure and externalizing domain behavior problems in 8-year-old children.</description><subject>Adult</subject><subject>Age</subject><subject>Aggressiveness</subject><subject>Behavior</subject><subject>Checklist</subject><subject>Child</subject><subject>Child Behavior Disorders - chemically induced</subject><subject>Child Behavior Disorders - epidemiology</subject><subject>Children</subject><subject>Children & youth</subject><subject>Children's Health</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Demographics</subject><subject>Environmental aspects</subject><subject>Esters</subject><subject>Exposure</subject><subject>Families & family life</subject><subject>Female</subject><subject>Health</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Infants</subject><subject>Ionization</subject><subject>Linear Models</subject><subject>Liquid chromatography</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Mass spectrometry</subject><subject>Medical research</subject><subject>Metabolites</subject><subject>Mother and child</subject><subject>Personal grooming</subject><subject>Phthalates</subject><subject>Phthalic Acids - toxicity</subject><subject>Phthalic Acids - urine</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, Third - urine</subject><subject>Prenatal exposure</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Prenatal influences</subject><subject>Psychological aspects</subject><subject>Regression</subject><subject>Studies</subject><subject>Taiwan - epidemiology</subject><subject>Urine</subject><subject>Womens 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exposure to phthalate esters and behavioral syndromes in children at 8 years of age: Taiwan Maternal and Infant Cohort Study</title><author>Lien, Yin-Ju ; Ku, Hsiu-Ying ; Su, Pen-Hua ; Chen, Suh-Jen ; Chen, Hsiao-Yen ; Liao, Pao-Chi ; Chen, Wei-J ; Wang, Shu-Li</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c745t-39dad977c9675afa7d3ca4a094e933882cad5e069cda5ce4af0ddd8315b216cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aggressiveness</topic><topic>Behavior</topic><topic>Checklist</topic><topic>Child</topic><topic>Child Behavior Disorders - chemically induced</topic><topic>Child Behavior Disorders - epidemiology</topic><topic>Children</topic><topic>Children & youth</topic><topic>Children's Health</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Demographics</topic><topic>Environmental aspects</topic><topic>Esters</topic><topic>Exposure</topic><topic>Families & family life</topic><topic>Female</topic><topic>Health</topic><topic>Health aspects</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Infants</topic><topic>Ionization</topic><topic>Linear Models</topic><topic>Liquid chromatography</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Mass spectrometry</topic><topic>Medical research</topic><topic>Metabolites</topic><topic>Mother and child</topic><topic>Personal grooming</topic><topic>Phthalates</topic><topic>Phthalic Acids - toxicity</topic><topic>Phthalic Acids - urine</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, Third - urine</topic><topic>Prenatal exposure</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Prenatal influences</topic><topic>Psychological aspects</topic><topic>Regression</topic><topic>Studies</topic><topic>Taiwan - epidemiology</topic><topic>Urine</topic><topic>Womens 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Risk</collection><collection>Civil Engineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environmental health perspectives</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lien, Yin-Ju</au><au>Ku, Hsiu-Ying</au><au>Su, Pen-Hua</au><au>Chen, Suh-Jen</au><au>Chen, Hsiao-Yen</au><au>Liao, Pao-Chi</au><au>Chen, Wei-J</au><au>Wang, Shu-Li</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prenatal exposure to phthalate esters and behavioral syndromes in children at 8 years of age: Taiwan Maternal and Infant Cohort Study</atitle><jtitle>Environmental health perspectives</jtitle><addtitle>Environ Health Perspect</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>123</volume><issue>1</issue><spage>95</spage><epage>100</epage><pages>95-100</pages><issn>0091-6765</issn><eissn>1552-9924</eissn><abstract>Few studies have shown an association between prenatal phthalate exposure and adverse effects on neurodevelopment and behavior in young children.
We aimed to assess the relationship between prenatal exposure to phthalate esters and behavior syndromes in children at 8 years of age.
A total of 122 mother-child pairs from the general population in central Taiwan were studied from 2000 to 2009. Mono-methyl phthalate (MMP), mono-ethyl phthalate (MEP), mono-butyl phthalate (MBP), mono-benzyl phthalate (MBzP), and three di-(2-ethylhexyl) phthalate (DEHP) metabolites-mono-2-ethylhexyl, mono-2-ethyl-5-hydroxyhexyl, and mono-2-ethyl-5-oxohexyl phthalates (MEHP, MEHHP, and MEOHP)--were measured in maternal urine collected during the third trimester of pregnancy using liquid chromatography-electrospray ionization-tandem mass spectrometry. Behavioral syndromes of children at 8 years of age were evaluated using the Child Behavior Checklist (CBCL). Associations between log10-transformed creatinine-corrected phthalate concentrations and standardized scores of the CBCL were estimated using linear regression models or multinomial logistic regressions with adjustments for potential confounders.
Externalizing problem scores were significantly higher in association with a 1-unit increase in log10-transformed creatinine-corrected concentrations of maternal MBP (β = 4.29; 95% CI: 0.59, 7.99), MEOHP (β = 3.74; 95% CI: 1.33, 6.15), and MEHP (β = 4.28 ; 95% CI: 0.03, 8.26) after adjusting for the child's sex, intelligence, and family income. Meanwhile, MBP and MEOHP were significantly associated with Delinquent Behavior and Aggressive Behavior scores. The same pattern was found for borderline and/or clinical ranges.
Our findings suggest positive associations between maternal DEHP and dibutyl phthalate (DBP) exposure and externalizing domain behavior problems in 8-year-old children.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences</pub><pmid>25280125</pmid><doi>10.1289/ehp.1307154</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-6765 |
| ispartof | Environmental health perspectives, 2015-01, Vol.123 (1), p.95-100 |
| issn | 0091-6765 1552-9924 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4286269 |
| source | Jstor Complete Legacy; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Adult Age Aggressiveness Behavior Checklist Child Child Behavior Disorders - chemically induced Child Behavior Disorders - epidemiology Children Children & youth Children's Health Cohort analysis Cohort Studies Demographics Environmental aspects Esters Exposure Families & family life Female Health Health aspects Health risk assessment Humans Infants Ionization Linear Models Liquid chromatography Logistic Models Male Mass spectrometry Medical research Metabolites Mother and child Personal grooming Phthalates Phthalic Acids - toxicity Phthalic Acids - urine Pregnancy Pregnancy Trimester, Third - urine Prenatal exposure Prenatal Exposure Delayed Effects Prenatal influences Psychological aspects Regression Studies Taiwan - epidemiology Urine Womens health |
| title | Prenatal exposure to phthalate esters and behavioral syndromes in children at 8 years of age: Taiwan Maternal and Infant Cohort Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T22%3A55%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prenatal%20exposure%20to%20phthalate%20esters%20and%20behavioral%20syndromes%20in%20children%20at%208%20years%20of%20age:%20Taiwan%20Maternal%20and%20Infant%20Cohort%20Study&rft.jtitle=Environmental%20health%20perspectives&rft.au=Lien,%20Yin-Ju&rft.date=2015-01-01&rft.volume=123&rft.issue=1&rft.spage=95&rft.epage=100&rft.pages=95-100&rft.issn=0091-6765&rft.eissn=1552-9924&rft_id=info:doi/10.1289/ehp.1307154&rft_dat=%3Cgale_pubme%3EA402483515%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1661373006&rft_id=info:pmid/25280125&rft_galeid=A402483515&rfr_iscdi=true |