Snail recruits Ring1B to mediate transcriptional repression and cell migration in pancreatic cancer cells

Transcriptional repressor Snail is a master regulator of epithelial-mesenchymal transition (EMT), yet the epigenetic mechanism governing Snail to induce EMT is not well understood. Here, we report that in pancreatic ductal adenocarcinoma (PDAC), elevated levels of the ubiquitin E3 ligase Ring1B and...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2014-08, Vol.74 (16), p.4353-4363
Hauptverfasser:	Chen, Jiangzhi, Xu, Hong, Zou, Xiuqun, Wang, Jiamin, Zhu, Yi, Chen, Hao, Shen, Baiyong, Deng, Xiaxing, Zhou, Aiwu, Chin, Y Eugene, Rauscher, 3rd, Frank J, Peng, Chenghong, Hou, Zhaoyuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Cell Culture Techniques Cell Line, Tumor Cell Movement - genetics Cell Movement - physiology Enhancer of Zeste Homolog 2 Protein Epithelial-Mesenchymal Transition Female HEK293 Cells Humans Male Middle Aged Pancreatic Neoplasms Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Polycomb Repressive Complex 1 - genetics Polycomb Repressive Complex 1 - metabolism Polycomb Repressive Complex 2 - genetics Polycomb Repressive Complex 2 - metabolism Protein Binding Snail Family Transcription Factors Tissue Array Analysis Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic Transfection
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