Transcriptome‐wide analysis of trypanosome mRNA decay reveals complex degradation kinetics and suggests a role for co‐transcriptional degradation in determining mRNA levels

Summary African trypanosomes are an excellent system for quantitative modelling of post‐transcriptional mRNA control. Transcription is constitutive and polycistronic; individual mRNAs are excised by trans splicing and polyadenylation. We here measure mRNA decay kinetics in two life cycle stages, blo...

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Veröffentlicht in:	Molecular microbiology 2014-10, Vol.94 (2), p.307-326
Hauptverfasser:	Fadda, Abeer, Ryten, Mark, Droll, Dorothea, Rojas, Federico, Färber, Valentin, Haanstra, Jurgen R., Merce, Clemetine, Bakker, Barbara M., Matthews, Keith, Clayton, Christine
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Enzymes Gene Expression Profiling Gene Expression Regulation High-Throughput Nucleotide Sequencing Microbiology Ribonucleic acid RNA RNA Stability Trypanosoma - genetics
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