Oxidative dearomatisation: the key step of sorbicillinoid biosynthesis† †Electronic supplementary information (ESI) available: Containing all experimental details. See DOI: 10.1039/c3sc52911h Click here for additional data file

A new biosynthetic pathway to the sorbicillinoid natural products is proposed based on the observation of oxidative dearomatisation of dihydrosorbicillin 10b . An FAD-dependent monooxygenase encoding gene (SorbC) was cloned from Penicillium chrysogenum E01-10/3 and expressed as a soluble protein in...

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Veröffentlicht in:Chemical science (Cambridge) 2013-11, Vol.5 (2), p.523-527
Hauptverfasser: Fahad, Ahmed al, Abood, Amira, Fisch, Katja M., Osipow, Anna, Davison, Jack, Avramović, Marija, Butts, Craig P., Piel, Jörn, Simpson, Thomas J., Cox, Russell J.
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Sprache:eng
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