A molecular toggle after exocytosis sequesters the presynaptic syntaxin1a molecules involved in prior vesicle fusion

Neuronal synapses are among the most scrutinized of cellular systems, serving as a model for all membrane trafficking studies. Despite this, synaptic biology has proven difficult to interrogate directly in situ due to the small size and dynamic nature of central synapses and the molecules within the...

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Veröffentlicht in:	Nature communications 2014-12, Vol.5 (1), p.5774, Article 5774
Hauptverfasser:	Kavanagh, Deirdre M., Smyth, Annya M., Martin, Kirsty J., Dun, Alison, Brown, Euan R., Gordon, Sarah, Smillie, Karen J., Chamberlain, Luke H., Wilson, Rhodri S., Yang, Lei, Lu, Weiping, Cousin, Michael A., Rickman, Colin, Duncan, Rory R.
Format:	Artikel
Sprache:	eng
Schlagworte:	14/33 14/63 631/80/313/1481 631/80/313/2378 631/80/86 Animals Botulinum Toxins - pharmacology Botulinum Toxins, Type A - pharmacology Cerebral Cortex - cytology Cerebral Cortex - drug effects Cerebral Cortex - metabolism Embryo, Mammalian Exocytosis - genetics Gene Expression Regulation Genes, Reporter Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Humanities and Social Sciences Luminescent Proteins - genetics Luminescent Proteins - metabolism Membrane Fusion Molecular Imaging multidisciplinary Munc18 Proteins - genetics Munc18 Proteins - metabolism Neurons - cytology Neurons - drug effects Neurons - metabolism Primary Cell Culture Protein Binding Protein Transport Rats Rats, Sprague-Dawley Red Fluorescent Protein Science Science (multidisciplinary) SNARE Proteins - genetics SNARE Proteins - metabolism Synapses - drug effects Synapses - metabolism Synapses - ultrastructure Synaptic Transmission Synaptic Vesicles - drug effects Synaptic Vesicles - metabolism Synaptic Vesicles - ultrastructure Syntaxin 1 - genetics Syntaxin 1 - metabolism
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