TSPAN12 is a critical factor for cancer—fibroblast cell contact-mediated cancer invasion

Communication between cancer cells and their microenvironment controls cancer progression. Although the tumor suppressor p53 functions in a cell-autonomous manner, it has also recently been shown to function in a non-cell-autonomous fashion. Although functional defects have been reported in p53 in s...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-12, Vol.111 (52), p.18691-18696
Hauptverfasser:	Otomo, Ryo, Otsubo, Chihiro, Matsushima-Hibiya, Yuko, Miyazaki, Makoto, Tashiro, Fumio, Ichikawa, Hitoshi, Kohno, Takashi, Ochiya, Takahiro, Yokota, Jun, Nakagama, Hitoshi, Taya, Yoichi, Enari, Masato
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antibodies beta Catenin - genetics beta Catenin - metabolism Biological Sciences Cancer Cell growth Cell Line, Tumor Cells chemokine CXCL6 Chemokine CXCL6 - genetics Chemokine CXCL6 - metabolism coculture Coculture techniques Cultured cells Deoxyribonucleic acid DNA Down regulation Epithelial cells Fibroblasts Fibroblasts - metabolism Fibroblasts - pathology Gene expression regulation Gene Knockdown Techniques genes Humans Lung cancer metastasis Mice Mice, Inbred BALB C Mice, Nude Mutation neoplasm cells Neoplasm Invasiveness neoplasms Neoplasms, Glandular and Epithelial - genetics Neoplasms, Glandular and Epithelial - metabolism Neoplasms, Glandular and Epithelial - pathology Proteins secretion Signal Transduction Smooth muscle Stromal cells Tetraspanins - genetics Tetraspanins - metabolism Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors
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