Nitric Oxide Represses Inhibitory κB Kinase through S-Nitrosylation

Nitric oxide (NO) possesses antiinflammatory effects, which may be exerted via its ability to inhibit the transcription factor, NF-κB. A commonly proposed mode of action for inhibition of NF-κB by NO involves interference with NF-κB binding to DNA. Because activation of inhibitory κB kinase (IKK), t...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-06, Vol.101 (24), p.8945-8950
Hauptverfasser:	Reynaert, Niki L., Ckless, Karina, Korn, Solange H., Vos, Nanda, Guala, Amy S., Emiel F. M. Wouters, van der Vliet, Albert, Yvonne M. W. Janssen-Heininger, Ignarro, Louis J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antiinflammatories Biological Sciences Cellular immunity Chemiluminescence Epithelial cells Gels Immunoprecipitation Oxides T lymphocytes Western blotting
Online-Zugang:	Volltext
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